AND CHLOROSIS. — In severe anemia, whether primary or secondary, bone-marrow has given better results than in pernicious anaemia. Here it would find a logical application, espe cially if, as thought by Quine, it repre sents an assimilable preparation of iron. The marked increase of hmmoglobin and the general improvement noted, espe cially in Mann's cases, would seem to warrant further trial of the remedy.
Trial in two cases of anemia and two of chlorosis; doubtful whether the bone marrow treatment is superior to iron. J. S. Billings, Jr. (Johns Hopkins Hosp. Bull., vol. v, No. 43).
Administration of the medullary glyc eride has shown better results than that of iron or arsenic. Danforth (Amer. Med.-Surg. Bull., May 16, '96).
Twenty-two insane male cases of amemia treated with bone-marrow. The average increase in red corpuscles was 1.361,439. The percentage of haemoglobin increased on an average of 12.5 per cent. The leucocytes, which in nearly all were abnormal at first, decreased in number at the end of the month. The whole general appearance in the majority of the cases improved. Appetite was better and
the action of the bowels more regular. Mentally, one case began to improve at once and soon went home recovered. Three were regarded as much improved and four others were brighter and had lost a great deal of the apathy they formerly had. In the remaining four teen the only improvement noticed was in their physical condition. Best results obtained with an extract made at the hospital by finely-chopped ribs of sheep and adding glycerin in the proportion of one pound to twelve ribs. This was per mitted to macerate four days. It was then strained through gauze and was ready for use. W. O. Mann (Amer. Jour. of Insanity, Jan., '97).
Ten cases of anemia and chlorosis treated by a preparation of nucleo albumin and bone-marrow, shown in the table. D. D. Mats (N. Y. Med. Jour., Oct. 30, '97).
1 of marrow; it is not precipitated by boiling; it does not contain iron, and may possibly be a deuteroproteose. Fowler (Scottish Med. and Surg. Jour., Sept., '99).