Case of cretinism in which mental as well as physical condition improved. Immediately upon the exhibition of the remedy and at the close of the first week a decided decrease in weight was ob served. At the end of the first two months he had lost twenty-two pounds and gained over an inch in height. Gen eral condition, physical as well as mental, has considerably improved. H. H. Vinke (Med. News, Mar. 21, '96).
Cretin child under treatment by thy roid about two years in an intermittent and rather unsatisfactory manner, af forded clear proof of the value and potency of the treatment. Every time it was begun the child underwent a rapid and striking improvement; every time the treatment was neglected the child relapsed into its former cretinoid appear ance, although it never became so had as it was at first. Finlayson (Glasgow Med. Jour., May, '96).
Case of a cretin, nearly 18 years old, so stunted as to be easily mistaken for a child aged 2 or 3 years; she could not stand or walk or speak. On October 15th she began taking half of a 5-grain thyroid tabloid daily, and within the first week she became much brighter and quicker in noticing things; she also lost one and three-fourths pounds. During the second week she lost two pounds more; made very ill, hot, feverish, rest and three-fourths inches in the first year of treatment, four and one-fourth inches in the second year, and two and one-half inches in the third year. In two adult cretins, 36 and 39 years of age, the growth in one was three-fourths of an inch and five-eighths of an inch in the first and second years, and none in the third. J. Thomson (Brit. Med. Jour., vol. ii, p. 618, '96).
Cretins whose bones show signs of less, parched, and thirsty. During the third week she lost one and one-half pounds more, and became still brighter and quicker. Both physical and mental improvement during the first six months. W. Rushton Parker (Brit. Ned. Jour., June 27, '96).
Case of a child, 5 years of age, seven inches below the normal height at the beginning of treatment, who grew five softening should be kept lying down as they would be in ordinary rickets. Victor Horsley (Brit. Med. Jour., Sept. 25, '96).
During thyroid treatment the rapid growth of the skeleton leads to a soft ened condition of the bones, which re sults in a yielding and bending of those which have to bear weight; as cretins under treatment become more active and inclined to run about, this tendency to bending has to be guarded against. If
any bending of the bones of the legs appears, the child should not be allowed to walk for a time, or the legs should be supported by light splints. The diet should be generous, and the child should get plenty of sunlight and open air. The administration of codliver-oil and Par rish's food would probably prove bene ficial at the same time. T. Telford Smith (Lancet, Oct. 2, '97).
Case in which all the symptoms of in fantile myxtrdema were present: idiocy, tins. M. II. Fussell (Med. and Surg. Reporter, Feb. 20, '97).
Three cases in two brothers and sis ter. The two older marked cretins, the younger being quite a typical case, while the baby has the cretinoid tend ency well marked. Thyroid treatment instituted. The baby's present condition is quite that of a normal child. The cases of the two older are less promising as to final results, although they have shown improvement in many ways. C. S. Caverly (Med. Record. Apr. 10, '97).
dwarfism, absence of the thyroid gland, retarded dentition, pachydermic denti tion, etc. Effects of thyroid treatment remarkable. Suspension of treatment: reappearance of almost all symptoms. Treatment was resumed and child trans formed physically and intellectually. Bourneville (Le Frog. Med., Mar. 0, '97).
Three cases improved markedly after taking thyroid three times a day in 1-grain doses; they could be classed with those mentioned by Horsley as being born with but few, if any, signs of the disease, and who gradually become Four cases of cretinoid myxcedema in which thyroid extract in small doses (2 grains twice a week) was used with success. It is a great deal better to begin with small doses two or three times a week, even if the desired results are obtained more slowly. than to deluge the patient with it. J. C. Shaw (Brook lyn Med. Jour., Jan.. '97).
Case of a child, nearly S years old. typical of cretinism, put under desic cated thyroid 1 grains t. i. d., but, the remedy being administered irregu larly, the patient was taken into a hos pital. It was then found that 6 grains daily was her maximum dose, and on this amount she very rapidly improved. At the end of four months (seven from the beginning of treatment) she had gained four inches in height, four pounds in weight, and had begun to act like a normal child. Dickson L. Moore (Colum bus Med. Jour., Apr. 13, '97).