Results obtained from the use of ovary juice in various diseases of women, especially those peculiar to the meno pause. In 51 eases, 34 of NI hich were personal, the results warrant the follow ing conclusions: 1. The troublesome symptoms of the natural menopause dis appeared or were greatly diminished by the use of the ovarian extract without any other medication. 2. Similar effects were produced by the administration of that substance in the relief of symptoms —for instance, irritability of the blad der — that follow surgical operations which have for their result the suppres sion of the menstrual flow. 3. Rapid improvement is constantly seen in chlo rosis and dysmenorrhoea. 4. The influ ence of extract of ovary on the psychical disturbances which accompany or are dependent on genital lesions are unde niable. 5. Rapid and permanent im provement in the general state. 6. Cli macteric metrorrbagia without neoplastic lesions yield rapidly to the administra tion of the remedy. 7. Its therapeutic action on the nervous system is manifest from the first day of its administration. Author states that he will shortly pub lish the results of laboratory researches as to the chemical constitution of the substance which be prescribes. C. Jacobs (La Policlinique, Dec. 1, '96).
Ovarian extracts act directly for the relief of the disturbances attending the menopause, either natural or artificial. Its use is also valuable in amenorrhcea, dysmenorrhoea, and in aniemia of ovarian origin. Good results have also been noted in some cases of simple oophoritis. Jayle (Revue de Gynec. et de Chir., No. 4, '98).
Oophorin preparations given to women suffering from acne rosacea and cutane ous disorders at the menopause, with satisfactory results., E. Saalfeld (Ber liner klin. Wocb.. No. 13, '98).
Extract of corpora lutea, to which the value of ovarian extract is due, adminis tered to patients suffering with the sub jective phenomena commonly following the menopause, thought to be due to ovarian insufficiency. In two cases in which this substance was used, the same results as those obtained from the ovarian extract were noted. A. Lebreton (Lancet, July 15, '99).
The nervous disorders following re moval of the ovaries or uterus were also found to be relieved by Landau and Mainzer, but only temporarily.
Knauer has shown that in rabbits the ovaries can be removed and then trans planted in other than their normal posi tion. They can be attached to the peri toneum as well as implanted between muscle-fibres. Thus implanted, the ovary is nourished and continues its function. Might this not be repeated in the human subject to antagonize the symptoms following aphorectomy or castration for hypertrophied prostate? Case in which bilateral oflphorectomy was followed by flashes of heat, profuse sweating, headache, and marked sensa tions of pressure in the occipital region preceding and during the early part of the menstrual period. Three-fourths to
5 drachms of ovarian substance admin istered twice a day caused the attacks of flashes of heat and sweating to become less frequent and severe. This was fol lowed by general improvement. Stachow (Monat. f. Geburtschulfe u. Gyn., B. 4, H. 1).
In disorders of any kind resulting from uterine affections, it seems to merit further trial.
Four cases of chlorosis treated for fourteen days with rest in bed alone, then a second period of fourteen days with ovarian extract. A relatively larger increase of hmmoglobin in the second series, and in three of these a larger in crease in weight. The menses appeared in two after an absence of some months. Muret (Rev. MCA. de la Suisse Rem., July 20, '96).
Ovarian extract is harmful to chlo rotics because the influence of the ovary upon the organism is of a chemical nature. The only form of opotherapy which offers any prospect of success in chlorosis is the medullary. U. Arcangell (La Riforma Medica, No. 91, '99).
Bone-marrow.
On the assumption that the red blood corpuscles were produced mainly from the red bone-marrow, J. Dixon Mann, of Manchester. utilized an extract of this substance in anemia and other condi tions dependent upon a depraved condi tion of the blood. The cases have been numerous in which the results have ap parently supported Dixon Mann's hy pothesis, great and rapid proliferation of the red corpuscles having been noted.
Case of pernicious anemia in which bone-marrow was employed in consider able success. Heemocytes, 1,S60,000 to 1,460,000 per cubic millimetre; hemo globin, 2S to 30 per cent. Three ounces of uncooked bone-marrow from the ox given by the mouth daily. After twenty seven days the lilumocytes numbered 3,900,000 per cubic millimetre and the hmrnoglobin amounted to 78 per cent. Fraser (Brit. Med. Jour., No. 1744, '94): The tissue-forming power of young animals being taken as a criterion, the marrow obtained from them was thought to be preferable to that of older animals. The best results were obtained from the marrow contained in the ribs of a young animal. The coarse marrow from the long bones contains a great deal of fat, which does not contain the specific virtues to the same extent as the finer medullary substance.
Preparation. — The method of prep aration advocated by the majority of writers is that recommended by Dan forth, of Chicago. The anterior extrem ities of calves' ribs arc comminuted so as to expose the cancellated tissue, and the fragments are placed in a jar and covered with glycerin, to the influence of which they are exposed for three or four days, being occasionally agitated. At the end of this time the liquid is strained, and the resulting fluid presents a reddish, syrupy appearance, without pronounced odor, and with the taste of glycerin. At first a teaspoonful of this extract is administered thrice daily.