Older observers had noted a diminu tion of fibrin, and as a result au abnor mal fluidity of the blood that predis posed to limmorrhage. Lowering of the rate and tension of the pulse and of the temperature, sometimes of nearly two degrees, was also noted: all evidences that the remedy had been administered in injudicious doses.
Bichloride, in high toxic doses, exer cises a noxious influence on both the white and red cells of the blood. In small amounts it affects the white corpuscles more markedly than the red bodies. The minimum fatal quantities for the organ ism correspond to the smallest amounts necessary to destroy the leueocytes; the same relation exists in regard to the largest quantities tolerated by the econ omy and those which are borne by the leucocytes; and it can ne said that at present there is no histological elelnent so susceptible to the influence of the drug in question as human lencocytes. E. Maurel (Bull. Gjn. de Then, Mar. 15, '93).
KinxE-vs.—The observations of Wel ander tend to show that the elimination of mercury through the kidneys is at tended by more or less temporary irrita tion when the drug is administered for some time. Casts were found in the urine in all of his 97 cases, in propor tion to the length of the trcatinent, gradually decreasing after cessation and disappearing within a month or six weeks. It is well to bear in mind, how ever, that his data are based -upon ob servations in syphilitic eases, and that the disease may bear considerahle influ ence upon the renal phenomena.
Syphilitic path-gas 1111(101- mercurial troalfne111 frcqueutly (10volop nopliritiq.
Out of too patienk, S had (10N-doped rons0q1101100 of the :11)• sorption of mercury. These P114(.4 't-1, lid tO tee0Nit) 011 the ces•altion of the ttttig I trbringer 'Med. IVeck. July 13, \, the quantity of urine. vari - r. parations were found, by Win :. t diiT,r in no way. Ins -,i‘;.t,z int huh d the insoltible salts, \late of mercury. and the solu t.r,parations. A parallelism between -!” (ID:int:iv introduced and the curative wds. shown by the quantity ex , !, hither the mode of administra w. s by the mouth. subcutaneous in ..., local inunction, or plaster.
-study t.f limination of mercury in 2S 1. It is eliminated hy sweat as .11 as by urine. When mercury is in tr. thittil in the system in quantity the t Math ii is increased: with cessation . I the drug. elimination is diminished.
Mercury is eliminated by the skin in argtr ammints than is supposed. The t iminated amount depends upon the cunt sw eat. 3. During immetions reury is pressed in the glandular ducts, bt nee it is removed by sweat. 4. By it r -ed sweating the remaining, Hg, can be o mired from the system. V. V. :Miro Vratch, vol. xx. No. 2S. '99).