In asylum rractice hyoscine has largely supplanted morphine in the treat ment of acute mania, the violence of acute melancholia and of general paresis, and as an hypnotic in general. It is remarkable for the absence of untoward after-effects. Hyoscine is most service able in cases of cerebral disease requiring an anodyne. After the administration of small doses of hyoscine in suitable cases the sleep produced is quiet and refreshing, and the system remains free from the after-headache, nausea, hebe tilde, and constipation that follow in the wake of opium and other narcotics.
Administration of hyoscine of value in cases of senile trembling, paralysis agi tans, and fibrillary agitation. In cases of chorea, and of various spasmodic af fections of the nervous and respiratory systems, hyoscine may be given hypo dermically, in doses of from to V,. grain. Roberts Barth°low (Med. News, Dec. 12, 'DI).
For the tumultuous heart's action of Graves's disease application of ice to the prcordium recommended, and, for a general sedative, hyoscine hydrobromate. Taylor (Med. News, Dec. Hi, 23, '93).
Tried in five cases of hystero-epilepsy, and it was found that it would abort an incipient attack and one already devel oped, a dose of grain usually being sufficient. Tolerance was not estab lished. Bela Nagy (Pester Medisinisch chiru•gische Presse, Nos. 3, 9, '94).
Hyoseine employed in a case of angina pectoris believed to be of neurotic origin, with excellent results. Ostwick (Med. Record, May, '97).
Many years' constant use of hyoscine has shown that patients do not behave the same under its administration. Old
people, particularly in feeble health, are more profoundly affected by even moder ate doses. If, after increasing the dose to grain, the desired effect is not ob tained, it is useless to increase it further. Frequent doses are not required, two hi twenty-four hours being usually suffi cient. It produces sleep normally by allaying cerebral excitement and morbid motor activity. Nothing like curative effects have been obtained. H. S. Noble (Yale Sled. Jour., No. S, 1900).
Hyoscyamus has anodyne powers and has been used in griping pains and neu ralgias, and is often added to purgative pills to lessen the griping effect. It has been used with success in strangulated hernia, its effects—anodyne and anti spasmodic—serving advantageously to overcome the constricting ring in mild cases.
Case of strangulated inguinal hernia in which reduction could only be ac complished after the patient had taken, dosimetrically, 30 granules of hyoscya mine and the same number of granules of sulphate of atropine, followed by 45 grains of chloral-hydrate in 1 ounce of the syrup of morphine. Lemarie' (Jour. of Med. and Dosimetric Thera.p., Apr., '91).
Left crural hernia reduced, after taxis had failed, by means of belladonna oint ment and ice to the tumor and the internal administration. frequently re peated, of hyoseyamine and strychnine. Berruyer (Jour. of Med. and Dosimetrie Therap., Apr., '91).