Experiments apparently proving that the main action of the drug is upon the nervous system, not in its peripheral por tions, but rather upon the spinal cord and brain. Batten and Bokenham (Brit. Med. Jour., June 1, 'o9).
Experiments sustaining Batten and Bokenham as to the effect of the drug upon the spinal cord, and in its local and general action as a sedative to the sensory nerves. Also in accord with most observers in the statement that antipyrine does not affect the circulation to any extent in moderate doses. Simon and Hoch (Johns Hopkins Hosp. Bull.: Apr., '90).
The deleterious effects manifested in the cutaneous system are very varied. There may be merely a sensation of great itching or burning without the appear ance of any eruption, which disappears rapidly upon the discontinuance of the drug. If an eruption appears, it may take the form of erythema, urticaria, petechim, or papule, or resemble in ap pearanee one of the exanthemata: measles, scarlatina, etc. In rare cases we note discoloration of the face and of the mucous membrane of the mouth, swelling of lips, tongue, and salivary glands, with epileptoid attacks, amauro sis, tinnitus, deafness, and delirium. In rarer cases the ingestion of anti pyrine is followed by the appearance of albuminuria, hxmaturia, ischuria, or strangury.
Urticaria produced rapidly by a single dose of 10 grains of antipyrine. E. Knight (Brit. Med. Jour., May 13, '95).
Case in which entire surface of the body was covered with a copious erup tion exactly resembling in appearance that of a severe case of measles; the face and eyelids were also swollen, after taking 10-grain powders of antipyrine twice daily for three weeks. No symp toms of cardiac depression appeared to be produced by the drug. Webber (Lan cet, June 6, '96).
Case of a gouty person of 65 years, who had often taken antipyrine without bad effects. One day a dose of 30 grains caused aphthous stomatitis, while an in jection of 15 grains produced an ulcera tive stomatitis with a pmTural eruption. Dalche (Med. News, Feb. 13, '97).
Case of a woman of 33 years, who, several hours after the ingestion of anti pyrine, developed a general pemphigus like eruption upon the skin and also upon the buccal mucous membrane.
This condition lasted ten days. There was also a scanty urine, but no albu minuria. Opinion that eruptions are only likely to occur in persons with renal lesions. Lyon (L'Abeille Mad., Mar. 27, '97).
Case in which there was (edema of the lower extremities and the vulva, with blebs forming under the skin after full doses. These symptoms ceased when the drug was stopped. Goldschmidt (L'Abeille Mad., Mar. 27, '97).
Case of a woman who had syphilis in 1394, for which she was thoroughly treated. Near three years later syphi litic manifestations appeared, which dis appeared under treatment. In April.
1393, she took 7 grails of antipyrine on account of headache, and on following day had a crop of vesicles in the mouth, which soon disappeared. A few days later she took another dose of 7 grains of antipyrine. In the same evening she shivered, and was feverish, and had an urticarial eruption over the body. On the next day there were numerous ves icles on the mucous of the cheek, soft and hard palate, upper and lower lips, and also on the vaginal mu cous membrane. Patient thought this relapse of the syphilis. In four days vesicles began to dry up, but food was taken with difficulty. Urticaria-like rash had now disappeared. Nothing but sim ple treatment used. Immerwahr (Ber liner klin. Woeh., Aug. 22, '93).
In some cases there is a marked re semblance between antipyrine poisoning and the algid stage of cholera.
Case in which there was severe col lapse, cold extremities, vomiting, hoarse voice, and sunken eyes. The stools, how ever, were solid, and there was a deep. rose-red rash on the patient's body. His radial pulse could not be felt. He an swered questions slowly, complained of headache and noises in his ears, and had disturbed vision. He had taken 2 drachms in 15-grain doses twice daily. Recovery under the use of stimulants. Guttmann (They. Monat., Oct., '92).
Case of a girl of 20 years, who took Si grains of antipyrine for the relief of headache. She did not lose conscious ness, but the pulse became almost imper ceptible, reaching 200 per minute. She recovered under absolute rest, strong coffee internally, and ice externally. Krysinski (Gazeta Lekarska, No. 33, '93).