Case of leukmmia in which there was priapism with cessation of sexual excite ment. The autopsy showed that the cor pora cavernosa had become transformed into homogeneous connective tissue. Kast (Zeit. f. kiln. Med., B. 8, II. 1, 2, '95).
Dyspncea is almost constant and does not depend entirely on the anwmia, but is, in part, toxic. CEderna of the glottis or of the lungs may occur. Laryngeal ulcerations may produce grave danger, as may mediastinal or cervical pressure. Pleural effusion is rare. Epistaxis is common.
Leukmmia changes in the larynx and trachea usually consist of numerous small nodules in the mucous membrane of the larynx and respiratory mucous mem branes, or less frequently slight diffuse infiltrations. Ebstein (Wiener klin. Woch., s. 462, '96).
Case of leukmenic infiltration of the larynx. At the autopsy there was found perichondritis of the arytenoid cartilage in addition to the leukmmic infiltration. The periosteum in the right half of the larynx was evidently partly infiltrated by thc leukmmie and partly by a simple inflammatory process. In the left half the infiltration was purely leukeemic. Mager (Wiener klin. Woch., No. 26, '96).
Changes in the larynx and in the trachea in cases of leukemia. Case of a boy, aged 13 years, who had attacks of severe dyspncea-, with croupy cough. Laryngoseopical inspection revealed great thickening of the ventricular bands, and infiltration of the whole upper portion of the larynx. The child died with severe dyspncea, aphonia, and bleeding from the mouth and nose. On post-mortem exam ination it was found that the infiltration of the larynx and bands was due to a dense collection of lymphocytes in fhe submucous tissue. The capillaries, also, were distended with lymphocytes, and these cells were especially abundant in the interglandular spaces. The submu cons tissue in the trachea NN as affected in the same way. Otto Barnick (Manch. med. Woch., Apr. 19, '98).
The temperature is rarely normal for any length of time, a low irregular fever being seen at some period in most cases. Chills rarely occur, but may be without signi ficance.
Case of leukmmia under observation for three and a half months; there was daily rise of temperature followed by a gradual fall during the whole period.
Von Hajek (Wiener klin. Woch., May 20, '97).
Exophthalmos may be produced by post-orbital collections. Leukmmic reti nitis occurs in many cases, often accom panied by retinal hmmorrhages; it may cause no symptoms, or may produce amaurosis. Dimness of vision may be present without retinal lesions. Tinni tus aurium and vertigo are common; deafness may be rarely due to hemor rhage into the internal ear.
Three autopsies in which it was deter mined that exudations and hmmorrhages in the middle and internal ears were the cause of ear disease in leukaemia. Lan nois (L'Union 1\I6d., Feb. 16, '91).
Case of leukfemia in which sudden vertiginous attacks simulating MeniOre's disease occurred. Subsequent anatom ical examination disclosed a. fibrinous collection in the utricle and saccule of the vestibule, with here and there more de cided evidences of hemorrhage. Lannois (Lyon MM., Jan. 3, '02).
Aural lesions appeared in 10 male and 5 female patients suffering from leu keemia. The aural afTection took the form of niore or less pronounced deafness, usually tending to rapid aggravation, and accompanied by tinnitns, and often vertigo. lir a certain number of instances t hese symptoms eonst it uted triad. The anatomical lesions consisted in the accumulation ot leueocytes, and the occurrence of hannorrliages both in the medullary spaces of the petrous bone and other parts of the auditory appara tus, and particularly in the internal ear. Schwabach (Zeit. f. Ohren., '97).
Case of leukremia presenting a peculiar affection of the eyelids, which at first had the aspect of cedema, but on closer ex amination proved to be small lymphatic tumors which ere not adherent to the skin. Litten (Med. Bull., :gar., '97).
Case of leuktemia complicated by !Hemorrhage into the anterior chamber of the right eye. Sorger (Mtinch. med. Woch., Aug. 30, '93).
Headache, insomnia, neuralgic pains, and depression are almost constant. Delirium may occur, toxic in origin; coma, when present, is usually due to intracranial tumor or hmmorrhage. Pe ripheral neuritis is uncommon.