11 y podermie injections of a rsen ic recommended in leukemia. Fowler's so lution is painful, but a solution of arsen ite of soda 2 grains to the ounce in doses of V„ to grain has been used with ex celent effect. Rummo (Rif. Aled., No. 1894, '94) .
Bone-marrow has beeri used with some success, and, given with arsenic, it has seemed to heighten its action.
case of splenic myelogenous leukcemia made worse by bone-marrow. C. E. Nam mack Pled. Rcc., Jan. 4, '96).
Extract of spleen is of no value. Iron is of value in the periods of apparent convalescence, but has -no influence on the leukfemic progress.
Case of a boy, 101/2 years old, with a considerably-enlarged spleen and a pro portion of one bite to ninety red cor puscles. The condition was cured by oxygen-inhalations. Kirnberger (Deut. med. Woch., No. 41, 'S3).
Oxygen-inhalations employed in case of lymphatic leukaemia without success. The gas employed. however, was dilute, being one-third nitrogen, and of this mixture 2S quarts were inhaled daily; whereas. in the cases of Da Costa and Hershey, the oxygen was perfectly pure and given in much larger amount, the maximum dose being 105 quarts per diem. Kahler (Inter. klin. Blind., Aug. 11, '89).
Two eases of leukmmia treated by in halation of oxygen. One of which, a boy of 13, was cured; and the other, a man of 35, greatly improved, and apparently on the way to recovery. The improve ment in each case dated from the com mencement of the oxygen-inhalations. Da Costa and Hershey (Amer. Jour. of the Med. Sciences. Nov., '89).
Case of splenic successfully treated internally with small doses of perchloride of mercury. E. Mondigliano (La Pediatria, Apr., '93).
Carbonie-acid gas administered to two cases of leucoeythmmia. Oxygen was administered simultaneously and galva nism was applied to the region of the spleen for five minutes before, as well as during, the sitting. in both cases, one in a boy, the other in a young woman. there aS perceptible diminution in the size of the spleen. Ewart (Brit. Med. Jour., July 23, '98).
All treatment in acute leukeemia has thus far been useless. Every case has progressed to a fatal termination un modified by the various forms of treat ment employed. M. H. Fussell and A. E.
Taylor (Phila. Med. Jour., Jan. 7, '99).
Local treatment over the spleen or en larged glands, blisters, cauterization, the local applications of iodine, cold douches, and electrical treatment may alleviate the symptoms to some extent.
Excision of the spleen or of glands is contra-indicated both by theory and by unfortunate experience.
The various systemic disturbances— cough, anorexia, vomiting, diarrhcea, cedema, serous effusions, headache, somnia, and neuralgia—demand priate treatment. In case of pressure -upon large vasc-ular trunks or trunks surgical interference may be in dicated.
The treatment should be designed to place the patient under the most favor able hygienic conditions,—in a healthy, bracing climate on a dry soil, with good air, good food, and favorable surround ings,—and he should, if possible, be free from all sources of worry or mental emotion. The most valuable drug is arsenic, which should be commenced in small doses and gradually increased. All the above indications may probably be best hilfilled by sending, the patient to undergo a course of arsenical waters at Bourboule, in France (Department Puy-de-Dome). Cold donches with the galvanic and faradic currents may pos sibly be useful. Quinine and iron are often employed, and oxygen inhalations may be tried, but are probably only re sorted to in the later and more hopeless stages. The operation of spleneetomy is hardly justified from the present pathological stand-point as a rational proceeding; but it has also against it the terrible objection that, out of 24 operations, only 1 patient has recovered. The chief danger seems to be that in leukinic patients the blood has lost the power by which normal Minostasis occurs, and the cut surfaces continue to bleed from vessels which offer nothing that the surgeon can tie. Transfusion appears to be useless. Ewart has recom mended the inhalation of carbonic-acid gas, but no one has confirmed his favor able opinion of this treatment. The enlarged spleen may be supported by a bandage or belt, and the stomach troubles are relieved by the administra tion of small doses of dilute mineral acid after meals. Robert Saundby (Brit. Med. Jour., Jan. 5, 1901).