From 1 to 1 '/, drachms of the follow ing solution may be injected at a dose without danger: li lodoform, 15 grains.
Guaiaeol, 75 grains.
Sterilized olive-oil, 3 ounces.—M.
There were 424 injections given to eighteen patients suffering from pulmo nary tuberculosis; the effects are dis tinctly favorable. The injections should be given into the loose connective tis sues of the back, shoulder, or thigh.
Careful asepsis should be maintained. A. Breton (Jour. des Praticiens, Dec. 19, '97).
The mction of guaiacol injections in surgical tubercle studied. The liquid is used as a 1-in-I0 to 1-in-20 solution in sterilized olive-oil. Rigid antiseptic pre cautions are required for the injections, the latter being made with a Roux syr inge deeply into the granulation-masses, to 1 cubic centimetre of the solution being injected at three or four different points. This may be repeated once or twice every week, provided there has not been much irritation.
Number of observations of white swell ing, etc., in which an extremely favor able result was obtained.
Guaiacol may also be used in the form of a dressing in certain open tubercu lous conditions: thus gauze steeped in guaiacol solution (in olive-oil 1 in 10) and applied to the surface causes de crease of pain and the healthy condition of the tissues. Gri.goire (These de Paris, FEVER.—Guaiacol possesses strong an tipyretic powers. It is perhaps best used by painting over the skin of the abdo men, the chest, or the internal aspect of the thigh, 30 or 40 drops being used for this purpose, as described above. These applications may be repeated. The de cline in temperature is often great and rapid, hut after reaching the lowest point the temperature will more rapidly attain its former height. A great feeling of depression is experienced by the patient and profuse sweating occurs. The tem perature has reached the minimum, and chills at this time are not uncommon. The use of this drug for its antipyretic effect is not devoid of danger, and its action is not as lasting as that produced by the cold bath and by numerous other antipyretic remedies. Guaiacol-carbon ate has been used in typhoid fever, for its antiseptic action in the bowel, but such use is not to be advised.
On painting the skin with guaiaeol in a case of typhoid fever, the temperature fell from 105.4° to 98.0° F. in three and a half hours without any disturbance of the circulatory or nervous system. Afterward the drug was used about twice daily, a fall of temperature occur ring each time. The antipyretic effect is slower than that of the bath, but more permanent. After washing with soap and water, 30 drops should be slowly rubbed in the skin of the abdomen or thigh or painted over the surface, then covered with lint or wax-paper. Fifty drops should be a maximum amount. The urine should be watched carefully. The unpleasant odor caused by the drug may be to some extent overcome by the addition of oil of cloves. Da Costa (Med. News, Jan. 27, '94).
Use of guaiacol not recommended, as, although the fall of temperature is very marked, the sweating and rigors are very severe, and the influence on the disease is not lasting. Stolzenburg (Berliner klin. Woeh., Jan. 29, '94).
Guaiacol mixed with tincture of iodine used in the treatment of pleurisy, in the following proportions: Tincture of iodine, 3S5 grains; guaiaeol, 75 grains. The chest is thoroughly painted with it every night. The application is followed by a fall of the temperature, profuse perspiration, diuresis, and by a resorp tion of the fluid. Casavovici and Miron Sigalea (N. Y. Med. Jour., Mar. 3, '94).
Guaiaeol applied externally is readily absorbed; its application is followed in most instances of fever by a gradual reduction in temperature, which reaches its lowest point between three and four hours after the application; the fall of temperature is almost always associated with profuse sweating; at a variable period, usually a short time after the lowest point is reached, the temperature rises rapidly, generally with marked chilly sensations, if not with an actual chill; the amount applied should rarely exceed drachm. Similar results fol low the absorption of gnaiacol through any other channel. Owing to the weak ening effects of its continued use and the disagreeable effects of its immediate application, its use as an antipyretic will be very limited. Thayer (Med. News, Mar. 31, '94).