In mental diseases antipyrine is con tra-indicated, its depressing influence upon the nervous system tending to aggravate the pathological process.
It sometimes prevents hallucinations and other sensory disturbances of reflex origin. In most cases, however, no effect is produced or the symptoms are aggra vated. Marandon de Montyel (Bull. Gen. de Then, Apr. 30, '93).
Antipyrine in doses of 15 grains re newed in two hours recommended to produce sleep. One to PI, drachms frequently given per day for a fortnight at a time, without ill effects. J. B. Tuke (Edin. Med. Jour., Feb.-June, '94).
RIIEukfATISM. — In the treatment of rheumatism and gout antipyrine holds a well-recognized position of merit, reliev ing the acute pains incident to those affections and controlling the fever as well. It is, however, less desirable than the salicylates in rheumatism or colchi cum in gout, and, moreover, is not de void of serious danger if there be any lesion of the heart or blood-vessels.
It often seems to act specifically in acute and subacute rheumatism, after salicylic acid has failed. It. Hirsch (Then. Monat., Oct., 'SS).
Case in which the temperature twice rose to 106° F., and was reduced by 10 grain doses of antipyrine. A. E. God
frey (Brit. Med. Jour., Nov. 4, '93).
Antipyrine used subcutaneously: 15 minims to 30 minims, followed by mass age at the point of injection, used in 130 cases of lumbago; 122 cured. The syringe should be carefully cleansed after use, as the antipyrine will ruin the in strument if allowed to remain. Excru ciating pain is produced, but it eontinif but half a minute. Bergquist (Eira, vol. xiv, No. 3, '95).
DIABETES.—Antipyrine has been rec ommended in the treatment of this affection, but its merits as regards the permanency of results have not been sustained by the experience of clinicians at large. Its continued use is likely to give rise to untoward symptoms.
It is valuable in diabetes, the glyco suria and other symptoms promptly and markedly diminishing under the use of the drug. Pousson (Jour. de Med. de Bordeaux, Oct. 11, '91).
While the favorable influence exercised is not to be doubted, the gastric intoler ance manifested by a number of cases prevented its continuance. Vergely (Jour. de MCd. de Bordeaux. Oct. 13. '91).
Antipyrine. in doses of from 5 to 7 grains, must not be continued more than eight to ten days. J. Mayer (Centralb. f. d. Gesammte Ther., July, '92).