PAINFUL DISORDERS.—The analgesic effects of guaiacol have been utilized in the treatment of arthritis deformans, acute articular and muscular rheuma tism, sciatic coxalgia, and pains of a superficial or deep-seated nature. The pains of orchitis and epididymitis are relieved by applying guaiacol in oily solu tion or in ointment (1 part to 10 or 15 of vaselin or lanolin).
In the treatment of epididymitis, an ointment composed of 2 to 5 parts of guaiacol and 30 of vaselin used with ad vantage. These good results may be explained by local action exercised upon the cutaneous nerve-endings, and the reflex action upon the cord and testicle, rather than by the absorption of the drug. Balzer and Lacour (Le Bull. Med., Apr. 11, '94).
When analgesic effects only are sought, the guaiacol should be used with equal parts of glycerin; but if it be de sired to produce an antithermic action, the drug ought to be used pure or else mixed with some vehicle that lends itself readily to dermic absorption. Ferrand (Provincial Med. Jour., July 2, '94).
Guaiacol used to relieve pain in acute articular rheumatism, tubercular caries of the wrist, hysteria, locomotor ataxia, arthritis deformans, with excellent re sults and without the development of disagreeable symptoms. The painful part is first cleaned, then from 0.73 to 1.5 cubic centimetres of guaiacol are rapidly applied with a camel's-hair brush. After employing gentle friction the part is covered with a piece of gutta-percha. In some cases relief was permanent; in others the pain returned the next day. Brill (Centralb. f. innere Med., Nov. '94).
Good results obtained in sciatica and intercostal neuralgia from painting a mixture of equal parts of guaiacol and glycerol over the course of the nerves. No ill effects were noted. Ferrand (Jour. des Prat., No. 30, '94).
Guaiacol recommended in pultaceous angina, phlegmonous tonsillitis, etc., in which diphtheria does not play any rule. Equal parts of glycerin and guaiacol for adults; 2 parts of glycerin and 1 of guaiacol for children. Affected parts to be painted four times in twenty-four hours, making the last application late at night and the first early in the morn ing. Darbouet (Jour. de Med. et de Chir. Prat., Jan. 10, '95).
Guaiacol recommended in cases of gon orrhceal orehitis. Crystalline guaiacol after previous melting may be applied to the affected part and to the groin by a brush; 31 to 46 grains may be used each time. A guaiacol ointment may be made thus:— 13,, Guaiacol, drachms.
Tavitian (Revue Gen. de Clin. et de Tber., Mar. 30, '95).
Results from the use of guaiacol in 52 cases of epididymitis, 50 of which were of gonorrhoeal origin. A 10-per-cent. oint ment made with vaselin or a 5-per-cent. used if the skin of the scrotum is ten der. The scrotum is first washed with soap and with ether. This ointment is ap plied during the acute stage, and in from three to five days the fever, pain, and swelling disappear. In subacute stages the action of guaiacol is less active and very slight in chronic cases. After the acute stage it is best replaced by a 1- or 2-per-cent. ointment of extract of bella donna, with equal parts of simple oint ment and unguentum diachyli. Salo' internally, 15 grains ter die, is a useful adjunct to the treatment. Lenz (Wiener klin. Ruud., Nos. 4, 5, 6, 'OS).
Guaiacol will render painless intramus cular injections of gray oil, oil with calomel. and especially oily solutions of biniodide of mercury, frequently em ployed for a long time in the treatment of syphilis. Lagrange recommends the following formula: 11 Sterilized olive-oil, 20 drachms. Mercury hiniodid., 6 grains. Synthetic guaiacol, 36 grains.
Should the physician inject every day, or every second day, in the region of the thigh, say, 30 grains of this solu tion, it will represent about grain of mercury biniodide. Bazin (Semaine Med., Mar. 22, '99).
A.N.XSTHESIA.—As an anaesthetic gua iacol may be used in minor surgical oper ations. A dose of 1 or 2 drops dissolved in sterilized olive-oil is sufficient to ob tain anesthesia; five minutes should be allowed to elapse after the injection. Championniere considers guaiacol supe rior to cocaine, because much larger doses may be used with safety. No acci dents were noticed except slight slough ing of the gums where it had been used for the extraction of teeth, which he attributed to a faulty method of injection or to a defective solution.