The ventricular bands usually require superficial and deep injections, the former to reach the deposits in the bands, and the latter the ventricles of the larynx. The interarytenoid space should be treated from below upward, otherwise it would be impossible to obtain a good view after the first injection. Very superficial puncture should be made in . the mucous membrane covering the arytenoids, as it is an easy matter to start a perichondritis in this situation. A row of injections should first be made around the base of the arytenoid. carti lages and gradually approach their tips. Tubercular infiltration. of the epiglottis renders it so thick and firm that it is capable of bearing considerable pressure and is readily subjected to this treat ment. A single row of injections may be made around the free border of the epiglottis about half an inch apart. The lingual surface of the epiglottis is very accessible for injection, but the laryngeal surface is not so easily reached. If the amesthesia is complete the epiglottis may, in some eases, be pulled forward sufficiently by the shank of the needle for the injections to be made. If this cannot , be effected, the needle may- be pushed through the cartilage from its lingual surface. After the injections the larynx should be kept as clean as possible, and sprayed every- day or so with the weaker solution of creasote. Chappell (N. Y. Med. Jour., Mar. 30, '95).
Creasote in lung affection is somewhat discounted by,, the irritant effects of large doses, leading to chronic inflammation of the alimentary tract. Creasotal (crea sote carbonate) was introduced to over come this advantage, and it breaks* up in the intestine into ereasote and carbonic acid. The decomposition is a, slow one; so that the organism is »iore or less con tinuously under the influence of croasote, whieli is excreted by the lungs and kid neys. It may be given alone in teaspoon fuls. or, if the patient is very susceptible to its slight taste, this may be covered by milk, sweet wine, etc. Very large doses (even 300 grains per day) can be administered without upsetting the di gestion. Just at first there may be some nausea, or even vomiting, but these do not contra-indicate the continued use of the drug, as they soon pass off. Crcasote carbonate has precisely the same specific action upon pulmonary tuberculosis as creasote; in addition it is of exceptional value in the symptomatic treatment, di minishing and deodorizing the expectora tion and improving the appetite, which may even become ravenous by its nse. It has a favorable influence on the gen eral condition, improving nutrition and leading to increase of body-weight, and so indirectly limiting the spread of the lung affection. It is to be preferred to creasote because of its milder action, and is indicated in cases where the latter is tolerated with difficulty or not at all. Reiner (Inter. klin. Rund., Sept. 15, '95; Brit. lied. Jour., Jan. 25, '96).
Creasote valerianate may be given in capsules, 3 minims thrice daily, and slowly increased until from 25 to 30 minims can be taken during the twenty four hours. Its use with thirty-five pa tients evidences it as an excellent sub stitute for pure creasote. Grawitz (Then Monats., vol. vii, '96).
Creasote possesses undoubted power to relieve the feetor pf foul expectoration in bronehiectasis analphthisis. It modifies
in a very appreciable manner the or dinary course of the latter disease. Shrady (Med. Rec., June, '96).
Creasote is one of the most efficient remedies in pulmonary tuberculosis. Probably no one drug exerts so favorable an action on the night-sweats, cough, and expectoration. It is of less value in cases accompanied by high temperature and hmmoptysis, and often aggravates these symptoms. It must be remem bered that many of the cases alleged to have been cured by creasote have been treated with eodliver-oil, tonics, and hygienic method, as well. In any event, large doses are necessary, and tolerance can usually be established by gradually increasing. Capsules are the least offen sive mode of administration, though some persons prefer to take the drug in milk.
Butler ("Text-hook of Mat. Med., Therap., and Pharm.," '96).
Creasote in full doses is strongly rec ommended in phthisis, especially in non febrile or only slightly-feverish cases. It is said to diminish expectoration, im prove appetite, and increase weight. A good formnla is R Creasote, 2 minims.
Com. tincture gentian, 15 minims. Rectified spirit, 20 minims.
Water, to make 1 ounce.
M. For one or two doses.
The creasote in this mixture may be increased up to 10 or even 12 minims without increasing the other ingredients. Ringer and Sainsbury ("Hand-book of Therap.," '97).
One hundred and three cases of pul monary tuberculosis studied. The dosage of crea,sote began with 5 minims three times daily, gradually increased to 25; also generous diet insisted upon, along with weighing at regular intervals. In. not a single instance was appetite un favorably influenced. Cough and ex pectoration steadily improved, and in most the physical signs were either the same or indicated less involvement of the lung. It is apparent that the remedy favorably influences the fever and night sweats, and that it is superior to others in that it does not interfere with, but rather favors, the nutrition of the pa tient. Jacob and Nordt (Berliner Charite-Annalen, S. 159, '97).
In the treatment of phthisis the drug is well borne. Of 23 eases, 6 were in the pretubercular state,—catarrh of the apices,—and 17 had already developed tuberculosis, and all were markedly benefited. Woodbury (N. -Y. Med. Jour., Sept. 4, '97).
WHOOPING-COUGH.—Both creasote and carbolic acid, by inhalation, often prove of great value in this malady, but it should riot be persisted in if they induce giddiness or a sensation of intoxication.
Creasote seems especially useful when the cough is -violent and protracted, and out of all proportion to the amount of expectoration, when, indeed, the cough seems largely to depend OD an excitable state of the nerves. Its effect is often rapid and complete; in fact, there are few remedies that afford, in some cases, so much and so rapid relief. Ringer and Sainsbury ("Ifand-book of Therap.," '97).
Brilliant results are had from the use of creasote, not only in plithisis, but in the sequels of whooping-cough, and the catarrh which often follows measles: two conditions which afford favorable oppor tunity for tuberculous infection. The usual treatment by means of expecto rants is too often without results. Hock (Tex. Med. Frac., Nov., '97).