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salicylic, acid, grains, salol, effects, salicylate, dose, acute and sodium

SALOPHEN. — Salophen (acetyl-para mido-phenyl salicylate) contains 50.9 per cent. salicylic acid. It occurs in fine, white, odorless and tasteless scales; solu ble in alcohol, ether, alkalies, and hot water, and nearly insoluble in cold water. It is not official.

Salophen was introduced as a substi tute for salicylic acid and salol by P. Guttmann (Berl. klin. Wadi., No. 52, '91). It is said to be less poisonous than salol or salicylic acid, because the phenol of the latter remedies is replaced by an in nocuous compound of phenol.

Dose and Physiological Action.—Salo phen, like salol, seems to suffer no action until it reaches the intestines, when the pancreatic juice splits it up into its com ponent parts, salicylic acid and acetyl paramido-phenol. As the latter appears innocuous, the further action of salophen is that of its contained salicylic acid. It has, however, certain advantages over the latter in that it is unirritating and tasteless and is not depressing. It may be given for considerable periods of time without causing nausea, anorexia, tin nitus, or other unpleasant symptoms. It possesses antiseptic, antipyretic, and anal gesic properties, and is given in doses of from 5 to 15 grains. The maximum sin gle dose is given as 20 grains; not more than 90 grains should be given during the twenty-four hours.

The results of a long series of obser vations on the use of salophen show that it is three times less toxic than salol. When taken by the mouth it passes through the stomach unaltered, and it is only in the intestine, when ex posed to intestinal and pancreatic secre tion, that it breaks up. The salicylic acid uniting with glycol is largely elimi nated in the urine, either as nascent salicylic acid or as salicylate of sodium. The acid phenol unites to the radical fanning a sulphate with that body. A certain amount of salophen is eliminated unchanged. There is evidence of the slow decomposition undergone by this substance, so that the organism is continually under its influence. There seem to be very few instances of intoler ance, and bad effects are also very rare. Salophen is free from smell or taste, and the most convenient method of adminis tration is in cachet. (Jour. de Med., Sept. 10, '97).

Therapeutics. — The therapeutics of this remedy are the same as those of salol and salicylic acid. It is given in the same cases, and in similar doses, and is generally to be preferred to either of them, for the reasons given above. It is well suited, also, for use in diseases of children.

The use of salophen avoids the toxic effects produced by some of the other salicylic comt,ounds. Fourteen cases of acute rheumatism were treated in the Bellevue Hospital by means of salophen, the drug being administered in 15-grain doses, along with 15 grains of sodium bicarbonate, every four hours. Analyzing the cases,—exeluding two, on the ground that the temperature was produced by other factors than acute articular rheu matism,—the averag duration of fever, after beginning to use salophen, was five days. According to Dr. Whipman, the

average duration of fever in 173 cases. treated with salicylates, was S.65 days.

There were no symptoms of gastric irritation, cardiac depression, or renal or cerebral involvement in any of the salo phen cases which could be attributed directly to the drug. Pearse (N. Y. Med. ,Tour., Mar. 14, '06).

Salophen has a most favorable influ ence upon psoriasis. The left leg of one patient was treated with 10-per-cent. chrysarobin-traumaticin, and the right leg with 10-per-cent. salophen salve. The better result was obtained with the hit ter method. Lehmann (Ther. Woch., Sept. 26, '97).

Salophen exerts an incontestable ac tion upon acute and subacute rheuma tism, but its effects are less constant than those of salicylate of sodium. In chronic and blennorrhagic rheumatism it has not shown itself superior to other drugs. Salophen possesses a powerful analgesic action, which is exercised even in those cases where this drug cannot be looked for to effect a cure. It has given good results in migraine, in various nen ralgias, and in sciatica. Salophen em ployed in a medium dose produces no phenomena of intolerance, nor does it oc casion headache, buzzing in the ears, or troubles of vision, but intolerance ap pears to be rapidly induced. In certain cutaneous affections salophen appears to have some efficacy. The medium dose of salophen is 60 grains daily, more or less, according to the gravity of the com plaint. Cresle (Gaz. Hebd. de 1116d. et de Chir., Dec. 1S, '98).

Salophen is harmless in daily amounts of from 45 to 90 grains. Since it is odor less and tasteless, it can be administered as a powder, in compressed tablets with starch or sugar of milk, or as pills. It passes through the stomach unchanged, without producing any gastric disturb ances, and in the intestine is so slowly broken up into salicylic acid and aceto parainido-phenol that the former acts in state nn..sc(ndi for a considerable period of time, but does not give rise to un toward action. It is an excellent anti rheumatic, acting in acute and subacute articular rheumatism equally as well as do salicylic acid and sodium salicylate, but without their unpleasant after effects. In chronic articular rheumatism it is no more useful than the above mentioned drugs. It is an excellent anti neuralgic and analgesic in cephalalgia, migraine, odontalgia ; facial, trifacial, and intercostal neuralgia; and in the nervous form of influenza. It produces good results in chorea. It acts well in various skin affections which are accom panied with itching: prurigo, urticaria, pruritus of diabetes, eczema, and psori asis. Dregs (Ther. Monats., H. 3, '93).