Hay fever successfully treated by su prarenal substance, all other measures being abandoned. Tabloids, representing 5 grains of suprarenal substance, were allowed to dissolve in the mouth every second, third, or fourth hour, according to the effects. If coryza or sneezing had begun, it would cease within fifteen min utes after taking a tabloid. The ac tion of the suprarenal substance is to raise blood-pressure by increasing the vascular tone, and this action may be local as well as general. To this effect in bringing about contraction of the vessels of the nasal mucous membrane relief experienced is attributed. S. Solis-Cohen (Phila. Med. Jou•., Aug. 13, 'OS).
In hay fever suprarenal extract is a most useful remedy. It will abort ordi nary acute catarrh. Used internally it has a marked effect in lessening the symptoms of hay fever, and gives marked relief to the patient in twenty four to forty-eight hours. When 5 grains are given every hour distinct local effects arc soon noticed. In certain patients some vertigo is noticed, the heart becomes a little more rapid than usual, and there is some nervous excite ment. There is but one possible incon venience that can be foreseen. If the drug should be used constantly and persistently, the lessening of the blood supply to the nasal tissues may lead to atrophy. The extract will abort asth matic tendencies and will frequently arrest asthmatic attacks, although it will not affect asthma when the affec tion is fully developed. When, as is often the case, the asthma is due to con gestion of the nasal passages, it will surely be benefited. Asthma on a gouty or rheumatic basis is also benefited. When the asthmatic attacks are asso ciated with an atheromatous condition, or are caused by interstitial nephritis, no relief is given. The extract may be applied on pledgets of cotton or by the spray every two hours until relief comes. The application or spray may be re peated whenever the symptoms return. H. 'Beaman Douglas (Med. News, Mar. 24, 1900).
A 6-per-cent, solution may be sprayed into the nose every two hours until the symptoms are controlled. Internally, 5 grains of the saccharated extract are given every two hours until some giddi ness or palpitation is observed, or until the vasomotor paralysis in the nose is brought under control. Then the dose should lie diminished, though the remedy should be continued until the hay-fever season is safely passed. B. Douglas (N. Y. Med. Jour., May 12, 1900).
Nitromuriatic acid in closes of 3 to 5 drops of the freshly prepared concen trated acid should be given after meals, and sometimes also at night, diluted with a half-tumblerful of water. After
taking this the patient should rinse out his mouth and swallow another hall-tum blerful of water. The hay-fever symp toms are usually relieved in forty-eight hours, but not a single dose must be omitted, or some symptoms will return. E. B. Gleason (Inter. Med. Mag., Aug., 1900).
Snuffing of a 1-per-cent. solution of trichloraeetic acid as a cure for hay fever used in more than 30 eases with the very best results. Improvement and cure follow in two to eight clays. II. Krause (Therap. Mounts., May, 1901).
Immunizing plan: i.e., 2 to 10 drops of the tincture of fluid extract of am brosia artemisite, in water, three times a day, during the two weeks preceding the time at which the paroxysm is ex pected; and, if need be, a nasal spray of suprarenal extract. Curtis (Med. Record, July 13, 1901).
;.Suprarenal extract gives favorable re sults when used locally, in simple vaso motor rhinitis without discoverable local abnormality or general dyserasia. In some eases, in which there is some local abnormality in the nose, it only acts fa vorably after the abnormal condition has been remedied, and then may be found unnecessary when rheumatism or other dyserasia exists, it causes some re action at first, but does not act as favo• ably as in uncomplicated eases. J. P. Clark (Boston Med. and Swig. Jour., June 19, 1902).
Nasal Reflex Neuroses. — These are usually ascribed to an impulse starting from the termination of a nerve of nasal mucous membrane through the inter mediary of a sympathetic centre and giving rise to morbid phenomena at a point more or less distant from the nose. Epilepsy, neuralgia, facial spasm, etc., have thus been traced to nasal disease. Whether the peripheral nerve-filaments, the nerve-trunk., their ganglia, or the entire system is at fault is hardly de terminable.
Reflex disturbances of the eyes are frequently observed as a result of hyper trophic rhinitis, atrophic rhinitis, polypi, etc. Cases of ciliary neurosis were cured by Seifert by division of nasal synechi. The connection between the nose and the eye mainly depends upon the nasal branch of the ophthalmic division of the fifth nerve. Cutaneous disorders are sometimes ascribable to nasal disorders, especially, according to Wells, the group known as the angioneuroses, including urticaria, herpes, pemphigus, erythema, etc.
Sensory Pharyngeal Neuroses.