Iodosalicylic and diiodosalicylic acids are iodine compounds of salicylic acid in which one and two atoms of hydrogen, respectively, are replaced by iodine. Di iodosalicylic acid contains 20 parts of iodine in 30, iodosalicylic acid 15 in 30. Iodosalicylic acid and diiodosalicylic acid are powerful antiseptics. They possess the combined action of iodine and sali cylic acid, and have been successful in the treatment of acute polyarticular rheumatism where salicylates have failed.
Loretin (meta-iodo-ortho-oxy-chinolin ana-sulphonic acid) is a bright crystalline powder, odorless, and similar in appear ance to iodoform. It is very slightly soluble in water or alcohol, and insoluble in ether, but forms soluble salts with alkalies, except with lime. Loretin is non-poisonous and unirritating, and has been used with good effect on burns, ulcers, and other wounds.
Losopliam (meta-tri-iodo-cresol) con tains 24 parts of pure iodine in 30. It is a grayish crystalline powder, soluble in alcohol, chloroform, oils, and fats. Loso phan has been found useful in parasitic skin affections, but it is apt to cause irri tation.
Sozoiodol (di-iodo-para-phenolsulpho nic acid) is composed of 54 per cent. of iodine, 7 per cent. sulphur, and 20 per cent. phenol. Sozoiodol has been found useful in the treatment of whooping cough: 3 grains blown into each nostril once daily. A solution of sozoiodol mercury with iodide of sodium has been recommended for intramuscular injec tion in syphilis. (Brit. Med. Jour., Sept.
18, '97.) Iodoformogen used as an application to recent wounds. After the bleeding had stopped the wounds were dusted with the powder, then sewn, and a thin layer of the powder applied over all. The wounds were, as a rule, rapidly and very satisfactorily healed. Wounds of 2 centi metres and larger, in which there was considerable tension, were also treated without suturing, in order to see if iodo formogen would be able, on account of its great adhesiveness, to firmly adhere to the margins and heal the wounds. As a rule, excellent results were attained in these cases. Schmidt (Amer. Medico Surg. Bull., July 25, '93).