The treatment by argentamin can be commenced at any stage of the disease, and usually insures a complete cure within a fortnight, no presence of gono cocci in the discharge after this time be ing discernible. In urethritis daily in jections of 1 in 2000 solution should be given. At first, after the injections, a slight increase of discharge is noted, but afterward this gradually and rapidly dis appears. In vaginitis the daily local ap plication of 1 in 1000 solution has been found most efficacious; while, in gonor rhoea] endometritis, swabbing the uterine cavity with a 5-per-eent. solution is to be recommended. Gordon (Med. Record, Nov., '90).
Argonin used in 15 cases of gonorrhoea. The gonococci disappeared from the dis charge in 9 days, on the average, without any noticeable symptoms of irritation be ing caused by the injections. After the germs had disappeared treatment with other astringents was continued for 21 days in order to complete the cure. A. Gattheil (Dent. med. Woch., No. 35, '96).
Best:Its of treatment of gonorrhica with argonin in 15S cases observed, the usual strength of the solution being 3 per cent. The writer infers that: (1 ) gonococci disappear from the urine in about three weeks under this treatment; (2) solutions varying in strength from 3 to 7 per cent. cause no irritation; (3) the cure in cases of acute, lurniorrhagie cystitis is prompt. Baltz (Monat. fiir prakt. Derm.; Centralb. f. Gyn., No. 21, '97).
The following treatment recommended for chronic gonorrhoeal urethritisi A solution containing alum, sulphate of zinc, and carbolic acid-1, drachm of each to 6 ounces of distilled water—is applied by means of an Ultztnann syr inge and soft catheter, first to the poste rior urethra beyond the compressor-ure thrm muscle, afterward to the anterior urethra in front of the compressor mus cle. On the first day the strength of the above solution is '/, ounce to 7 ounces of distilled water; on the second day, 6 drachms to 71, ounces; on the third day, 12 drachms to 7 1, ounces; on the fourth day, 12 drachms to 4 ounces. After this the discharge usually ceases, and nothing remains but a few shreds and turbid urine. Then weak solutions of silver nitrate arc applied in the same way, starting with 1 in 12,000, gradually increased in strength to 1 in 6000 on the fourth day. This is followed by passage of a sterilized sound into the bladder and allowed to remain there five minutes, after which 1 in 5000 silver-nitrate solu tion is again applied. This manoeuvre is
repeated every four days till the shreds are free from gonococci and pus. In cases where a morning drop of pus persists after the above treatment this is due to follicular involvement, which is treated by the application of 10- to 15-per-cent. silver solution, the follicles involved be ing found by the endoscope. If several large shreds persist after repeated use of full-sized sounds, there are probably granular spots which must be treated in the same way with silver nitrate. In jections are not recommended in the early stage of profuse discharge. Attention is called to lubrication of catheters and sounds with glycerin in place of oil, the latter preventing the solution used from coming into contact with the mucous membrane. Dowd (Buffalo Med. Jour., Aug., '97).
If gonococci are found in a discharge, the use of protargol should be commenced at once, and the injections should be used three times a day. At two of these ap plications the fluid should be retained for five minutes, while at the third the time may be prolonged to thirty minutes. After a few days one injection of pro targol daily will suffice, while at the other two occasions sonic astringent may be substituted. As the treatment is pain less, it can be continued for three or four weeks if necessary. The strength of the solution should at first be per cent., but it may soon be increased to 1,, and ultimately to 1 per cent.; excellent re sults have been obtained in cases of ure thritis in women by solutions of from 5 to 10 per cent. Protargol is the best, the safest, and the quickest remedy employed in the treatment of gonorrhoea. Neisser (Centralb. f. Derm., Oct., '97).
Protargol is better than any other silver preparation, used as a 1-per-cent. solu tion for the anterior urethra, and '/, to 1 per cent. for the posterior urethra. Gold enberg (N. Y. Med. Jour., Jan. 20, '98).
Largin is a gray powder produced by the action of an ammoniacal solution of oxide of silver on an alcoholic solution of the dry product of decomposition of the paranneleoproteids. In a solution of 1 in 4000 kills the gonococci. Kornfeld (Wiener med. Presse, Aug. 14, '9S).