When the stomach rebels against in organic iron, defibrinated bullock's blood may- be given by enema or some of the organic preparations may be adminis tered internally. In simple ancernia, fer ratin, in doses of 4 to S grains, may be given three times daily in wafers or pow der, with milk or other liquid food; chil dren easily take half the dose. 1-Immo globin, the red coloring matter of the blood, occurs as a brownish-red powder, which may be given in doses of 25 to 50 grains, in wine or syriip, three times daily. Hmmogallol, a preparation made from hmmoglobin, may be given in doses of 4 to S grains, three times daily, a half hour before meals, in powder with sugar, or in wafers, pills, or tablets. liEemol, also from Jammoglobin, is given in the same manner as the preceding, in doses of 4 to S grains. Iliemoferrum is an other preparation derived from bullock's blood; it is given in doses of 3 grains.
Another organic preparation that has found large use is liquor mangano-ferri peptonatus, or "pepto-mangan," a bland liquid, usually well borne by the stomach in doses of V, to 1 tablespoonful three times daily.
Care should be taken not to associate ferratin too closely with acid. Marfori (Annali di Chin]. e di Farm., Feb. 1, '94).
The daily amount of iron required is about 50 grains. Iron is supplied by vegetable foods of various kinds, and per haps in sufficient quantity for the needs of a healthy person, but not enough for one suffering with antemia. A larger quantity is furnished by animal food, particularly milk, eggs, liver, and blood. The combinations in the first three are stable, and therefore not so serviceable as those found in the last. Certain iron containing derivatives of blood ntay be used with success in anmmia. Of such, luemol and hmmogallol are particularly useful. In addition there are certain artificial products having definite value, among which is rated ferratin. Kobert (Deutsch med. Wadi., July 12, 19, '94).
Ferratin tried in fifteen cases in which iron was indicated, and in which the stomach was too irritable to tolerate the ordinary preparations. There was no di gestive disturbance produced by it; it did not increasd the quantity of Nemo glohin more rapidly than the other prepa rations of iron. Max Einhorn (Amer. Therapist, Mar., '95).
To small children ferratin is given in milk or other liquid foods, and it is found to be an excellent nourishment and one especially indicated for such children as arc deprived of their mother's milk and do not thrive well on the arti ficial products. G. T. Richardson (N. Y. Med. Jour., Apr. 18, '96).
Ferratin tried for specific blood-making effect in six cases confined in the Cagliari Clinic, and in five day-patients at their dispensary. Daily record kept of all de tails, including blood-corpuscle count by Thoma-Zeiss apparatus and Ittemoglobin estimation by the chroximeitometer of Bizzozero. From this report are quoted the conclusions:— Case I. December 270, 30 per cent. Inemoglobin; red corpuscles per cubic centimetre, 3,000,000; weight, 115 pounds.
Ten weeks later, 55 per cent. Inento globin; 4,000,000 corpuscles; weight, 122 pounds.
Case 2. December 21st, 28 per cent. lumnoglobin ; 2,800,0(30 corpuscles ; weight, 108 pounds.
Eight NI eeks later, 55 per cent. !Immo globin; 4,000,000 corpuscles; weight, 127 pounds.
Case 3. January 27th, GO per cent. luemoglobin ; 4,000,000 corpuscles ; weight, 147 pounds.
Three a ceks later, 85 per cent. hremo globin; 5,000,000 corpuscles; weight, 1541A pounds.
t 1 1 el tilar hill, 20 per cent.
2,00,41-too corpuscles : w, 4;1.1. s 1 polin.k.
NN t't later, .,5 per cent. Nemo.
taton.001) Lorrti.c10,: MI& I.-- \ rill 2.1. I.', per cent. lianno .1 Iwo :i3;110.11110 w,ight 1-01111‘k.
h II N1t'ck." later, per cent. hanno Jobut: 4.000.000 corpuscles: weight, 11t1 pounds. _1. Varese Onnali Farm. him.. July.
iron aets iu anannia by stimulating the blood torining proeess tlie bone 111.11TOW. alld Iltli by merely supplying th, iron necessary to the formation of an inureased amount. of hannoglobin. \\hen administered by the stomach it is ab-orbed. and is found in large quanti ties in the bone-marrow. as well as in the liver and spleen. ln animals ren dered aniemic by bleeding the erythro e? tr.- were rapidly formed and eame sooner to maturity. so that a larger number of them enter the circulation in a given time. in young healthy rabbits the bone-marrow became deep red when iron Iva, given. _1. Badman]] (Virehow's Arehiv. 11. No. 235-30(1, 1900).
,..4eries of 12 eases in which daily in jections of 1 cubic centimetre (15 min im-. of a 10-per-cent. solntion of am monio-eitrate of iron were used. Un pleasant. symptoms sometimes set in after the lapse of a few minutes to half an hour—namely. a sense of general heat. severe headache, vertigo, debility, sometimes an epigastric oppression and a feeling of (esophageal constriction, follolved in most eases by vomiting,. These symptoms often occur at the be ginning of the treatment, and then dis appear. only to return when the organ ism i- .-aturated with iron: but in this latter they ean often be prel-ented 1,.\ lengthening the interval between the -Vvoitling these liabilities to error, the author found that the locality of the injeetion had a very marked in the nee on the .eaairrence of the unpleas ant -yin pt inns. They occurred in grea ter LA- lc-s degree after 51 ont of 54 injec tion, 194.4 per cent.) in the dorsal re gion. but (mly in 17 out of 305 injections (5.3 per cent.) made in the gluteal
glut'. .1. I'lesNi degli Osped.,
In chlorosis the use of iron does not yield as good or as certain results as in aineinia; in fact, some cases are not bene fited at all by iron alone, but yield to a combination of iron and strychnine, or iron and arsenic.
It has been found by clinical experi ence that the long-continued use of iron may lead to impairment of digestion, headache, and other functional troubles. It is well, therefore, to make occasional intermissions and to give a purge mean while. It has also been found that good food, fresh air, and out-door exercise favor the assimilation of iron, although in some cases of profound amemia abso lute rest in bed has been found to hasten recovery.