Ten cases of ozmna treated with sub cutaneous injections of antidiphtheritic serum. Treatment was first commenced by injecting subcutaneously 20 cubic centimetres of the antidiphtheritic serum prepared in the bacteriological labora tory of the Copenhagen University. This serum has a strength of about 100 anti toxin units in each cubic centimetre. The dose was repeated a few days later. This dose was soon found to be too strong. By degrees it was found that 10 cubic centimetres was a proper dose for adults and 5 cubic centimetres for small children, the dose being increased now and then to 15 cubic centimetres in adults. It was found best to wait to repeat the dose until eight to twelve days have elapsed after the previous in jection. Opinion is expressed that the injection of antidiplitheritic serum is the most effective remedy for ozmna yet 10101V1). Holger Mygind (Jour. of Laryn., etc., Aug., '9S).
The use of the galvanic current recom mended by Shurly has been praised. The positive pole is applied to the back of the neck and the negative pole in the nasal cavities. The faradic current has also been used, as have the copper trodes, on the principle of electrolysis.
Experience with 6 eases of ozwna under treatment by electric light (in candescent). The light is directed by reflectors into the nose, or a lamp is actually introduced with a water-jacket into the nostril, or a larger lamp in the mouth is used, illuminating the nose through the transparent facial bones. In every case there was a noteworthy decrease of the crusts and secretion, and a disappearance of the characteristic fcetor. Two cases previously treated by the best means known, who had re turned with the usual odor in spite of nasal douches several times a day, are now free of the odor and use no irriga tion at all. Ign. Dionisio (Gaz. Med. Ital., Feb. 6, 1902).
Among the drugs which have been employed in this way are iodoform, iodol, aristol, salicylic acid, camphor, iodine, perchloride of iron, tannin, alum, rhat any, and opinm. Medicated bougies manufactured with a basis of gelatin and glycerin and medicated with the drugs just mentioned have been used a good deal in atrophic rhinitis, and this method by which drugs can be kept in contact with the mucous membrane for a. long time seems to be a reasonable one.
The inhalation of stimulating volatile substances obtained from the essential oils and from cubebs, tar, eucalyptus, and thymol has also been largely em ployed; and we find in the shops a num ber of varieties of so-called autoinsuffla tors, by means of which the patient is enabled to blow into his own nostrils the fumes of carbolic acid, menthol, oil of pine, ete.
Thymol used for four years W ith suc cess in atrophic rhinitis. Watery solu tion of the strength of '/, grain to I 'A grains to the ounce is applied in the form of a fine spray every other day, after careful cleansing with a weak al kaline solution. Cleansing should also be regularly practiced at home by the patient, 11 ho may then apply a solution of thymol in albolene by means of a few puffs from an albolene vaporizer. Wright (Med. Rec., Aug. 15, '91).
Among drugs which have given good results as stimulants in the treatment of atrophic rhinitis, thymol continues in the first rank; it may be used in W atery solution with alcohol and glycerin, but is much better employed dissolved in one of the petroleum oils; albolene, gly mol, or benzoinol may be used, the thy mol being in the proportion of from :3 to 10 grains per ounce.
Frontal headache, lacrymation, or a severe stinging sensation in the nose should always be regarded as indications for the use of a weaker solution. R. W. Seiss (Med. News, Nov. 2S, '96).
A somewhat different plan of treat ment, but intended to produce proper stimulation and secretion, is called "massage" of the mucous membrane. Laher, of Vienna, found this method of treatment most satisfactory. Cotton is wrapped around a probang introduced against the atrophic mucous surface and held in position by the left hand, while regular motion is made by vibrating the left arm with the right hand. After a few days normal secretion is established and the crusts become thinner and fewer in number.
Massage of the atrophied mucous membrane with a thin sound m around with a little eotton, and carry ing a 20-per-cent. pyoktanin lanolin oint ment, advised. 11y a gentle to and fro movement the entire diseased surface is stroked with the inedivated cotton. Demme (Med. Press and t'ireular, Aug. 19, '01).
The use of destructive agents in the treatment of this disease deserves only to be censured.
The use of hydrogen peroxide seemed for a time to promise great amelioration in this disease, and as a germicide niol •1 , tat t Aunty Is unquestioned.
L L.., I. %“.'11:r, ratitt r troublesome to cm d, %%11 le it produLes cleanliness, ti-,ful stimulant, but leaves the ii,e.mbrane quite as dry as be for . A strong solution is quite irritat im, aft! apt to produce a subacute naso riler, z.t. al catarrh.