The surest means for the diagnosis of pulmonary and nasal glanders is to in oculate some of the morbid products into cats and guinea-pigs, and to make control experiments with cultures on potato. If the animal dies of glanders, and the culture consists of the malleus bacillus, there is no longer any doubt about the disease; hut this as a diag nostic means is not always easy. Hei man has found a simpler means, in an extract of the malleus bacillus. This extract. called mallein, produces on horses attacked with glanders an eleva tion of tempera ture of from 0.9° to 5.4° F., and forms. at the seat of inoculation, a tumor which increases rapidly for two or three days and then disappears. Glanders is present whenever the above symptoms appear in the horse after the injection of mallein. This diagnostic procedure has already been adopted in the German army. Semmer and WIad inirow (Revue Internat. de Bibliog., June 25, '93).
Treatment.—When the cause is local, energetic measures should be pursued. The erosion or seat of infection should be completely removed by means of the knife, and cauterizing by means of the thermoeautery. Constitutionally, the administration of mercury has been ad vocated, but it is doubtful if the case would not prove fatal before the proper constitutional remedies could be had.
Owing to the certain amount of anal ogy between glanders and tuberculosis, the authors have used the creasote treatment, as well as Lannelongue's chloride of zinc, in glanders. The re sults have been found most satisfactory. Claudius and Michel (La Semaine Med., Aug. 24, '92).
Three cases of human glanders, one generalized and affecting especially the thorax, the other two localized, treated by gray ointment. The first case died the day after examination by the author. In the other two the abscesses were incised and disinfected, and friction with the gray ointment, 1 drachm daily, prescribed. Cure resulted in both. Gra levsky (Wratsch, No. 25, '93).
The injection of the serum of horses affected with glanders causes less rise of temperature in animals with the disease than the injection of mallein. Serum has been used for protective and curative, as well as for diagnostic, pur poses. In one troop of cavalry twelve horses were injected, and after this no more cases of pulmonary glanders ap peared. Repeated injections are neces sary for protection. Schneidemuhl (Brit. Med. Jour., Apr. 29, '93).