Endocrinopathies

arterial, genital, hypertension, syndrome, sexual, asthenia and secondary

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Myasthenia of Erb-Goldflam(?) : Head ache, ptosis, external ophthalmoplegia, fixed or transitory palsies principally of the face, the neck, myasthenic electrical reaction.

Thymus Loss: Idiocy of Klose and Vogt. Tetany( ?) : Basch.

Suprarenals.—Addison's Syndrome and Suprarenal Insufficiency: Asthenia, arterial hypotension, morning nausea and vomiting, lumbar pains, melanoderma, white lines on the skin, amyotrophy, aboulia, depression. At times myoclonus, epileptic attacks; tetany, periodic palsies, delirium, mental confusion, sudden death.

Suprarenal-genital Syndrome: External feminine pseudo-hermaphroditism with virile secondary sexual characters; suprarenal yin, ism ; amenorrhoea, gynecomasty, adiposis with easy bruising, all signs of feminine maturity; hypertrophy of the clitoris, hypertrichosis of masculine type, masculine voice, muscular and nervous hyperasthenia, active and violent sex ual inversion; arterial hypertension, arterio sclerosis; glycosuria.

Sympathetic Paraganalia.—Chromaffine cells of the solar plexus, aortic paraganglion of Zuckerkandl, cardiac paraganglion of Wiesel and Weisner, Luschka's carotid and coccygeal glands, tympanic paraganglia. The syndromy of the affections of these glands is entirely ob scure.

Pancreas.— Diabetes Mellitus: Glycosuria, ,polyuria, polyphagia, polydipsia; neuralgias, pruritus, impotency, constipation, dry mouth, dry skin, diminished perspiration, atrophy of the testicles, abolition of the tendon reflexes, arterial hypertension, asthenia, headache, sus ceptibility to cold, perforating ulcer of the foot, syncopies, comatose or apoplectiform at tacks, paralyses, vertigos, asthmatic dyspnceas, pseudoangina, narcolepsy, depression, apathy, hypochondria and coma.

Hypophysis.—Froehlich's Genital Adiposity Syndrome: Adiposity, arrest of development or regression of the genital glands of the genital organs and the corresponding secondary sexual characters; somnolence.

Syndrome of Hypophyseal Insufficiency of Renon and Delille: Tachycardia, instability of the pulse, arterial hypotension, insomnia, anorexia, distressing sensation of heat, exag geration of sweat secretion.

Acromegaly: °A simple hypertrophy, not congenital, of the upper and lower extremities and also cephalic,' headache, amenorrhoea, ten don reflexes increased, arrhythymia, syncope, perspiration,polyuria, glycosuna, sensitive ness to cold, neuralgias, acroparesthesia, cramps, lancinating pains, lassitude, irritability, depression.

Gigantism : eAcromegaly of the subjects in the epiphyseal cartilages which have not yet ossified,* impotency, amenorrhoea, indolence, infantilism, aboulia, asthenia, glycosuria, polyuria.

Pineal.— Genital Macrosomia: Abnormal increase in height, premature genital and sexual development with secondary sexual characters, hypertrichosis, exaggerated mental precocity.

Pineal Adiposity: Diffuse obesity.

Choroid Plexus.— Hydrocephalus: Hyper tension of the cerebrospinal fluid, rapid de velopment, nervous and mental syndrome of ventricular hypertension, obnubilation, idiocy.

Ovaries.— Infantilism: Amenorrhoea, ab sence of secondary feminine characters, obesity, deficiency of hair, childishness.

Acquired ovarian insufficiency. (a) Periph eral vasodilatation, subjective crises of heat, sweating, continuous or paroxysmal tachy cardia, palpitations, arterial hypertension, in somnia, severe headache, facial neuralgia, lum bago, neuromuscular asthenia, memory instabil ity, irritability, enervation, hysterical crises; exaggeration of the sexual instinct(?), more often absent or inverted; obesity, restlessness, anxiety, phobias, impulsions, gastrospasm, con stipation, vomiting, vertigo, syncope.

(b) "Vagotonic crises' before the menses and at the beginning of pregnancy, pallor, tendency to syncope, nausea, vomiting, consti pation, diminished arterial tension, pulse rather slow, oculocardiac reflex positive, Samogyus's sign, psychic depression particularly connected with the development of the corpus luteum. These crises occurring before menstruation or at the beginning of pregnancy must not be confused with the reactionary dyshyperthyroid ism of the menopause marked by flashes of heat, sweating, hypertension, paroxysmal tachycardia, palpitations, anxiety.

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