Thymus Loss: Idiocy of Klose and Vogt. Tetany( ?) : Basch.
Suprarenals.—Addison's Syndrome and Sup rarenal Insufficiency : Asthenia, arterial hypoten sion, morning nausea and vomiting, lumbar pains, melanoderma, white lines on the skin, arnyotrophy, abulia, depression. At times myoclonus, epileptic attacks, tetany, periodic palsies, delirium, mental confusion, sudden death.
Suprarenal-genital Syndrome: External femi nine pseudo-hermaphroditism with virile sec ondary sexual characters; suprarenal virilism ; amenorrhea, gynecomasty, adiposis with easy bruising, all signs of feminine maturity; hy pertrophy of the clitoris, hypertrichosis of masculine type, masculine voice, muscular and nervous hyperasthenia, active and violent sexual inversion; arterial 'hypertension, arteriosclero sis; glycosuria.
Sympathetic Paraganglia.—Chrontaffin cells of the solar plexus, aortic paraganglion of Zuckerkandl, cardiac paraganglion of Wiesel and Wiesner, Luschka s carotid and coccygeal glands, tympanic paraganglia. The syndromy of the affections of these glands is entirely obscure.
Pancreas.— Diabetes Mellitus : Glycosuria, polynria, polyphagia, polydipsia; neuralgias, pruritus, impotency, constipation, dry mouth, dry skin, diminished perspiration, atrophy of the testicles, abolition of the tendon reflexes, arterial hypertension, asthenia, headache, sus ceptibility to cold, perforating ulcer of the foot, syncopies, comatose or apoplectiform attacks, paralyses, vertigos, asthmatic dyspneas, pseudo angina, narcolepsy, • depression, apathy, hypo chondria and coma.
Hypophysis.—Froehlich's Genital Adiposity Syndrome: Adiposity, arrest of development or regression of the genital glands, of the genital organs and the corresponding secondary sexual characters ; somnolence.
Syndrome of Hypophyseal Insufficiency of Renon and Delille: Tachycardia, instability of the pulse, arterial hypotension, insomnia, an orexia, distressing sensation of heat, exaggera tion of sweat secretion. • Acromegaly: "A simple hypertrophy, not congenital, of the upper and lower extremities and also cephalic," headache, amenorrhea, ten don reflexes increased, arrhythmia, syncope, perspiration, polyuria, glycosuria, sensitiveness to cold, neuralgias, acroparesthesia, cramps, lancinating pains, lassitude, irritability, de pression.
Gigantism: "Acromegaly of the subjects in the epiphyseal cartilages which have not yet ossified," impotency, amenorrhea, indolence, in fantilism, abulia, asthenia, glycosuria, polyuria.
Diabetes Insipidus( ?) : Polyuria, polydipsia.
Pineal.— Genital Macrosomia : Abnormal in crease in height, premature genital and sexual development with secondary sexual characters, hypertrichosis, exaggerated mental precocity.
Pineal Adiposity: Diffuse obesity.
Choroid Plexus.—Hydrocephalus: Hyper tension of the cerebrospinal fluid, rapid develop ment, nervous and mental syndrome of ventric ular hypertension, obnubilation, idiocy.
Ovaries.— Infantilism : Amenorrhea, absence of secondary feminine characters, obesity, de ficiency of hair, childishness.
Acquired ovarian insufficiency: (a) Periph eral vasodilatation, subjective crises of heat, sweating, continuous or paroxysmal tachy cardia, palpitations, arterial hypertension, in somnia, severe headache, facial neuralgia, lum bago, neuromuscular asthenia, memory insta bility, irritability, enervation, hysterical crises ; exaggeration of the sexual instinct( ?), more often absent or inverted ; obesity, restlessness, anxiety, phobias, impulsions, gastrospasm, constipation, vomiting, vertigo, syncope.
(b) aVagotonic crises') before the menses and at the beginning of pregnancy, pallor, tend ency to syncope, nausea, vomiting, constipation, diminished arterial tension, pulse rather slow, oculocardiac reflex positive, Samogyus' sign, psychic depression particularly connected with the development of the corpus luteum. These crises occurring before menstruation or at the beginning of pregnancy must not be confused with the reactionary dyshyperthyroidism of the menopause marked by flashes of heat, sweat ing, hypertension, paroxysmal tachycardia, pal pitations, anxiety.