MALIGNANT TUMORS. — GOOd results have been obtained with methyl-blue in the treatment of epithelioma. It may either be injected, as in the case of super ficial neoplasms, when a 10-per-cent. so lution is to he used, or given internally in doses varying with the strength of the patient. It must be borne in mind, how ever, that under all circumstances re I •t. preferable, and •., o only be em NH(' cases.
int -nil, ring from villous r 11,61,I,r a pencil was ) the tAaniination-,, ound 9 , grains in pills C N., I tr,mment, begun March 6th, • “l by ,omplete cure, at the .1.ty 6th. Mosetig-Moor , .1, N1, I Jour.. July, '94).
NI. t tie tried in the treatment neoplasms of a malignant -v. It Vt.1", git en three times a day ' et I grain. in pill form, or asso _op(' A. ith b4.11adonna as a suppository: t..Iiin. 1 grain; extract of hello.
? , grain; cocombui.ter, 31 grains.
a of ronounced cancer of the an :.-tonishing result was the patient increased in weight, t'pe N.,1111t111°. and eructations ceased, and Lb- tut.- reappeared. O. Alaibaurn No. 43, '95).
cf epithelionia of the chin cured I) rstitial injections of a 10-per-cent. s lution of methyl-blue. At first ti( n of 25 minims was made every - ? Later the amount was de • and only one or two injections ire n.ade during a week. The entire 1- f treatment was six months. The atr...phied, and at the end of the yrird cf treatment only a fibrous eica +rix rcra-ine.l. Eight months later there L.= 1 n no recurrence. Dubarry (Rev. - "I, c-r.. r. 15. '97 .
- 't is necessary to com :7, CP S of methyl-blue with those f E:,..:17--e=.peeially chromic acid .7J1 zairan,•cautery, these being util ..' IT- ,:n!y de,troy the superficial f ta-c: of cancerous tumors Of ".. r•I idly cured by daily applica .. • .f t 20 ioctl yl-blue. It is, how r mrre efficacious and rapid in - e .ifIccted area be fir,t canter v ith chromic acid or with z. Iv.rm--autF-ry. In deep tumors it • i'd in:ectrd hypodermically; and, rre a large surface has been destroyed 1-7- th. =kin-grafts should be z I b.t.- ccn the fifteenth and twenty first days. Darier (T.a Sem. Med., May 23, '94).
Case of a woman, 57 years old, suffer ing with epithelioma of the face. The scabby surface of the epithelioma occu pied the entire right side of the chin from the hollow as far as the middle of the horizontal rarnus of the maxilla; vertic ally, it extended beyond the fold of the lower lip, and beyond the body of the maxilla. Tbe surrounding tissue was red,
hard, and (Edematous; and the lip was much thicker on the diseased side. The tumor was divided into four lobes, each one of which was covered with bloody scabs. When they were separated, a large quantity of bloody pus was dis charged. Tbe tumor was adherent to the periosteurn of the maxilla. Operation 1,-as refused and interstitial injections of methyl blue were tried, although without any hope of success. During the first applications, 30 grains of a 10-per-cent solution in distilled water were injected. Each time the entire diseased surface was saturated, the needle being pushed as deep as possible, until it touched the periosteum, the liquid being thrown in all directions. This was repeated as often as it was necessary. Lie tumor and all the red tissue surrounding it became of a bluish color. Several times hmmorrhages mere provoked, but they were not alarm ing or of long duration, and a slight compression rapidly arrested then).
After the first application the intense itching complained of disappeared. Dur ing the first three months an injection 1N-as given regularly every two days. the average quantity of liquid injected being 15 grains. After a month of this treat ment the tumor noticeably diminished in size. After the third month it had di minished one-half; cicatrization oceurred from the periphery toward the centre. As recovery approached, a more consider able resistance was felt; the tissues be came more compact and denser. During the fourth and fifth months of the treat ment only one or two injections a week were practiced; the quantity of liquid used was also diminished in proportion as recovery advanced, and during this stage not more than two or three di visions of a Prayaz syringe were filled for the injection. At no tirne did the patient feel pain in the kidneys or experience trouble on micturition. Five months after the first injections treatment was stopped; eight months later there was a firm cicatrix on the spot where tbe epithelionm had been, which was crossed in all directions by fibrous bands, which r ere very resistant to the finger and ad hered to the inaxilla. Dubarry (Nor mandie MM., Apr. 1, '97).