Methylene-blue used in twelve eases of acute nephritis, 4 '/;„ grains being given three times daily, every other day. The results were good. G. Leventhal (Wratsch, No. 22, '94).
Methylene-blue administered in a ease of chyluria due to the Filaria sanguinis hominis. The effects of the drugs were decided and prompt. Austin Flint (N. Y. Med. Jour., June 15, '95).
Methylene-blue is an excellent microbi cidc, it coagulates pus, it prevents fer mentation, and it is an excellent anal gesic when given internally. These prop erties determine its indications in various affections of the urinary system. G. Richard d'Aulnay (Bull. Giin. de ThC•r., Se liv., p. 352, '97).
Methylene-blue employed in S cases of alburninuria. In 5 of these there was rapid diminution; in 3 complete disap pearance of the albumin. The diseases represented were subacute and inter stitial nephritis, sometimes complicated with renal congestion. The doses em ployed varied front 1/3 to 3/. grain per day. Lemoine (Compt. Rend. de la Soc. de Biol., May 7. '97).
Methylene-blue is an analgesic, as is well known. Its property of staining axis-cylinders of rterves has suggested to Ehrlich that it might prove as analgesic in painful neuroses of which neuralgia is the main type. It was also found ef fective in reducing the pain or rhemna tism and sciatica.
On account of the properly of methyl. blue staining nerve-tissues. especially the axis-cylinder. this drug has been tried as an analgesic in the treatment of 25 cases of painful affections. Tt WRS used hail; hypodermically (15 gra /IS t 1 drachm of a 2-per-eent. solution) and in ternally by capsules (dose, '/,, to 15 grains per day). ln 15 minutes the urine NS s noticed lo be light green, in 2 hours. a bluish green, and in 4 hours a dark blue. The saliva and flues v, ere also colored, but the conjunctiva, skin, and mucous membrane remained free froin color. In 2 hours from the time of nd ministration the pain usually began to be relieved. Ehrlich and Lepprnann (Wiener med. Prcsse, .Tune 22, '90).
a lete relief obtained in neuralgias of tinknow it cause, of neuritis of ot ataxia in the second period, and of bone pains of tubercular, syphilitic, and trauma tie origin. Methylene-blue rdlt N ed. IN ith011t destroying entirely, termin muralrias, and the pains of sderosis of the spinal cord and those of subatnte articular rheumatism. Finally, the drug failed to act in the neuralgias f hysteria, in the laneinating pains of the cachettie period of tabes, and in those of acute articular rheumatism. The
dm?. NN USIlally given in doses of 3 grains a day. The untoward effects most commonly, although not frequently, ob strved were cephalalgia, nausea, and diarriara. Combemale (Bull. Gell. de Thc;r., Apr. 30. '91).
Methylene-blue used as an analgesic ith great success in neuralgia,, sciatica, and locomotor ataxia, 4 ‘/.., grains a day to be given. Lemoine (Le Bull. -Med., Apr. 21, '95).
Methylene-blue recommended in acute articular rheumatism. It has a favorable effect upon the local inflammatory proc ess in the joints and upon the general condition of the patients. J. R. Philpots Brit. :Med. Jour., Mar. 27, '97).
Methylene-blue is particularly valuable in those forms of rheumatoid arthritis due to autointoxication from the intes tinal tract. W. Armstrone (Brit. Med. Jour., Apr. 24, '97).
:Methylene-blue is valuable in habitual headache and hemicrania. It may be given in 1 '/,-grain doses along with equal parts of powdered nutmeg, the ob ject of the latter being to prevent irri tation of the bladder. E. Thomson (St. Petersburger med. Woeh., .May 30, '98).
_Methylene-blue tried as an analgesic in 27 cases of sciatica. In G cases the tains disappeared in five days, in 13 the sciatica persisted several weeks, but the pains N\ ere less frequent and the patients could sleep. No effect was observed in '3 cases. About 7 grains were given daily. 'light gastric disturbances were com tlained of; pain during mieturition was easily avoided by adding a little nutmeg to each dose. The drug first causes a numbness. which gradually changes into analtresia. Hence the necessity of eon tinning the drug NN hile any pain is felt. Klemperer (Mk.l. Mod., June 27, 1900). MALARIAL FEVEIZS.—Guttman and Ehrlich, basing their opinion upon the fact that methylene also stains the atozotin, were also led to consider this agent as of value in diseases in which the parasite was found. The remedy was also tried with apparent success by Thayer, of Baltimore, in doses averaging 1 7.2 grains five times a day. The only untoward effect produced, when given by itself, was that of strangury, but this was relieved by the ingestion of nutmeg. This unpleasant symptom. did not appear if the nutmeg were given from the be ginning.