Ferripyrin is a valuable styptic and astringent, having the advantage over perehloride of iron in not acting as ft caustic. When applied to the mucous membrane of the nose it acts as a power ful astringent and produces a slight an [esthetic effect. It is used in the form of an 1S- to 20 per-cent. solution, pledgets of cotton-wool soaked in this being ap plied to the bleeding-parts. For gonor rhma injections of 1 a/2-per-cent. solution may be used. In hromatemesis doses of 7 to S grains should be given. Jurasz (Then Monats., Feb., '95).
Ferripyrin has the same indications as perehloride of iron, with fe‘l cr objections. It appears preferable as an Inemostatic. C. Calderone (Arehivio de Pharm. e Tera., Feb., '95).
Ferripyrin, a new haemostatic, is a com bination of perehloride of iron and anti pyrine. It is a very fine orange-colored powder, soluble in water, the solution being deep red in color. It is intended as a substitute for perehloride of iron, and the indications for its use are the same. The dose for an adult is 7 V, grains in ternally, mixed with an oily, sweet prep aration of menthol. It is of value in gastrorrhagias. For external use and as an hremostatic, either the powder or an 18- to 20-per-cent. solution 'nay be em ployed, cotton tampons being saturated in the solution and applied to the bleed ing surface. In 1- and 11A-per-cent. solu tions it is reconnnended as an astringent in urethral blennorrhagia. Epistaxis in a case of nasal myonia was arrested in a very short time by the introduction of two small tampons soaked in ferripyrin. The drug is free from the caustic effects produced by perchloride. of iron. I,. Hed derich (Munch. med. Woch., No. 1, '95).
In hwmatemesis, 1 or 10 drops of the solution of the subsulphate, or pernitrate, well diluted in ice-water, will generally be followed by relief. The tincture of the chloride may be similarly used.
In intestinal hannorrhage iron is less beneficial, as it becomes converted into the inert sulphide as it descends the ali mentary canal.
SABORANDI.—Jaborandi (Pilocarpus, , 17. S. P.) is the dried leaflets of the South America trees Pilocarpus sellvanus (Rio Janeiro jaborandi) and Pilocarpus jabo randi (Pernambuco jaborandi), belong ing to the family Rutacece. The leaflets have an aromatic odor, and an aromatic, bitter, and pungent taste. When chewed they produce an increased flow of saliva. Jaborandi contains two alkaloids (pilo carpine and jaborine), a volatile oil, jaboric acid, and tannin. Chemically the two alkaloids are similar. The physio logical actions of the two alkaloids are widely different. The alkaloid pilocar pine is non-crystallizable, and occurs as a colorless or yellow syrupy liquid, which is soluble in water, alcohol, ether, and chloroform. The salts of pilocarpine are
crystallizable. The hydrochlorate is offi cial and occurs in white, hygroscopic crystals, of a slightly-bitter taste and of an acid reaction; it is soluble in water and alcohol, and does not keep well.
A preparation of pilocarpine previously active may suddenly lose all its power. II. Magnus (Ther. Monats., Feb., 'SS).
Jaborine is never used in medicine, and has an effect antagonistic to pilo carpine, or like atropine.
Preparations and Doses.—Pilocarpus, 5 to 50 grains.
Extract or extractum pilocarpi flui durn, 10 to GO minims.
'1 .0 11 iroelil. rale of pilocarpine (PO carp.n.t ltplrotd loras). tu 1„ grain.
I \ 1-4 of .1 11,(Nt. \\ it II 1.11o...11 pine, produced (ruin it by tile :te non of heat or alkali, as first noted Petit and Polonwasky, 1.-; confirmed. l'asc ime-tieators it the name of dot arpidine, but his should be re t aitwd for a base found in jaborandi It NN 114'11 has been partly described llornack and _Merck. As the new alkaloid isomeric with pilocarpine and easily formed from it, the author -tiertsts that it should be called pilot.;11.16110.- lts presence is proved as an impurity in the pilocarpine nitrate at present on the market. and in the alkaloid prepared from jaborandi leaves at present obtainable. llis experiments also show that it exists ready formed in the leaves. The existence of the pilocarpidine Ilarnack and _lerek and their statements regarding its composition are confirmed from an examination of some of the nitrate ob tained from Merck. Bnt the author proved that the jaborandi leaves at present on the market, consisting chiefly of l'ilocurpus inicrophyllirs, and the pilocarpine nitrate of commerce contain no piloearpidine. jaborine described hy Harnaek and Meyer as an alkaloid existine: in the mother-liquors of pilocarpine is shown to be a mix ture of pilocarpidine, isopilocarpine, with possibly a trace of pilocarpine and coloring matter. No alkaloid answer ing to the description of jaborine could he found in the leaves at present obtainable. Physiological experiments confirm the results of the chemical investigation with respect to the nature of jaborine. I'reliminary physiological experiments on isopilocarpine. pilo carpine, and pilocarpidine have been made by C. :Viarsliall, of University ollege. Dundee, who reports that the substances prodtice similar effects on the secretory activity of the sweat and salivary glands, pilocarpine being; much the most powerful. Isopiloearpine is eomparatively less depressant to the heart, of rabbits, but not to those of cats or man. The iaborine of Merck.