The mode of administering quinine is to be regulated in accordance with the exigencies of the case. In the milder forms of infection its administration by the mouth is the preferable mode, while in cases of severe grade, where quick action of the specific is all-important, and in cases in which the drug induces vomiting, its hypodermic administration is demanded. By the mouth quinine is best given in solution, notwithstanding its bitter taste, as in this form only will its prompt absorption be absolutely sured. If given in capsule, or as the much-resorted-to quinine pill, at best the absorption of the drug is delayed and at the worst may be passed off by the bowel within the undissolved capsule or coating. -Under certain circumstances it may be deemed advisable to give quinine in the form of rectal enemata; this is the least certain of all the methods of administering the drug, however, and should only be employed when for some reason its administration by one of the other methods is contra-indicated.
Tablets of quinine frequently pass di gestive tract without being absorbed; neutral tannate of quinine for prolonged use. Aufrecht (Ther. Monats.. July, '95).
[I heartily concur with Aufrecht, that quinine should never be given in the form of tablets. The ordinary pill of quinine— especially when sugar-coated or gelatin coated—I have frrquently discovered in the alvine disehaiges unchanged. I con sider the bichloride of quinine the best and most soluble form. It may be given in freshly-made gelatin capsules, but the cachets of the French—concave, paper like disks made of rice-flour—are the best. JUDSON DALAND, Assoc. Ed., An nual, '961 Microscopical observation of tbe effects of quinine on the blood of malarial pa tients (quartan type), who have not been treated ith quinine: .As the red corpuscle is necessary for the life of the parasite, quinine, by driving the parasite out of its element, places it under con ditions unfavorable and destructive to its development. Therefore quinine should not be given in the febrile stage of the disease, but during the non-febrile in tervals, when the early forms of the para site are present in the blood in greatest number. Lomonaca and Panichi (Cen tralb. f. d. med. Wissensch., Aug. 19, '99).
c.f t partici' ar salt of ! L . 1 ht _;11 11, 11 111111.1er of some • a. tilt fOlintl Ill Wirer L! Cii,,r11! Of their SOlithility 11. W.I.:0 Of tile alkilik1id t very slightly .L r. the sulphate of quinine . )--t commonly employed.
.1( r, nal:lily soluble in acid .0 that \Alien given in water 7 14nry to add sufficient sulphuric cf. t t, solution.
11 11 I I, 11 1.111' all 1111'111, (If 1.. 1111.11 111101•11011. W. S. Thayer (N. Y.
t/, NOV. '20, .97).
ptibility to quinine exhibited ne per-on- eau be nearly always giN in.! quinine hydro .. r tt or the bromitle-.• -fOr eX t,- le. t wiee nnleli brtuni(le of 6:odium Mtn-late of quinine favored -14,1,1 of the sulphate. Andrew • \led. lIcc., Jan. 15, '9ti Quibinc i- a pui-on to the plastru-alium, .•it. again-1 the toxin manu t .t the latter. The destruction n (.4.1.1in of red rolls by malarial ar,t-ite aid- in thermolysis„ and this de feet can be compensated by administer ing -.Itch remedie- as tend to increase Jrit..unt of hamoglobin in blood. at same time combining At ith i1 ,uelt antiperiodie quinine. \Varner (N. Y. Aled.
lour.. Dee. 1(1. .9•41.
Fifteen grains of quinine with 15 f powdered ginger twice a day.
• t.1 three dose- of ounce of tel tinet me of opium git eu in 47 cases f in-laria. Twenty-two were cured a,t hill]] 24 hours: 10 within 48 nrs, and 12 of the remaining 15 at ..t.r peri...1-: 3 were not benefited. No oentrred in any case. 'I'he para 111111111 in ino-t of these cases was of t.. J.-Ill...autumn:II type. In 6 eases v. a- mixed infection tvith typhoid .1 1 ria : 4 the-e got well of the daria during the course of the ty H., id, and in 2 the malaria reappeared Itc-r convale,cence front the typhoid fe-er. AV. If. Thomp-on (Med. News, . 17. *tc,...
Quinine should Ile administered only when required, and then given in suf ficient doses to destroy the parasites in the blood. The incubative period of malaria is certainly not less thelli fIVE days: therefore a person visiting a mai:trio:is district should take front 7 to 15 grains (0.46 to 1 gramme) of qui nine at bed-time on the fourth (lay, and he should repeat this every fourth or fifth day during his stay in the place or until eold weather puts a stop to the liability to infection; he should also sleep under a mosquito-bar and stay in-doors after sundown.
Small daily doses of quinine, 1 to 2 grains (0.06 to 0.12 gramme), simply habituate the parasites to the presence of the drug in the blood, and they con tinue their evolution in its presence.
Then an acid solution of qninitie is to be used.
Quinine. when combined with eatuphor and eapsiem». will cause the disappear ance of the malarial parasite from the blood more quickly than quinine alone.