Nitrate of potassitun very efficient in the treatment of chills and fever. Sixty five per cent. of personal cases cured with a single dose; 35 per cent. were uninflu enced by repeated doses. Best results were obtained when the drug was admin istered during the premonitory stage, in anticipation of the paroxysm. Twenty five or 30 grains at this period will abort the attack or modify its course and in tensity. Hunter (N. C. Med. Jour., Mar., '90).
Successful employment of methylene blue. Seven and one-half grains were given six hours in advance of the time of the expected attack, and. subsequently, 1 V,. grains or more five times daily. Guttmann and Ehrlich (Wiener med. Woch., Oct. 24, '91).
Methylene - blue unsuccessfully- em ployed in five cases, in hourly doses of 1.5 grains five or six times, as many hours in anticipation of the paroxysm. While it appeared to control the parox ysm, it did not prevent recurrence. Its use was also attended with irritability of the gastro-intestinal and genito-uri nary tracts. Ketli (Ungarisches Archiv f. Med., B. 2, H. 1, '93).
Methylene-blue etnployed in thirty-five cases of intense malarial fever: the drug exercises an influence upon the plas tnodia, as these were found to disappear and the paroxysms not to recur. The remedy was administered internally, or injected subcutaneously. The injections were given twice daily, 15 grains of from a 1-per-cent. to a 5-per-cent. solution of methylene-blue being used on each occa sion. The paroxysms did not recur after from three to five injections had been given. By the mouth capsules contain ing 6 to 7.5 grains were given twice or thrice daily. Unpleasant symptoms, such as headache, anorexia, and vomit ing, were in some cases observed to occur after internal administration. Porenski and Blatteis (Ther. Monats., Jan., '93).
Phenocoll is as effective as quinine in malarial-fever state, whereas quinine, in many instances, gives rise to toxic symp toms. Phenocoll has not been found to give rise to such unpleasant effects. Phenocoll succeeds in a certain number of cases in which quinine absolutely fails. The taste of the drug can easily be masked by means of syrup, and is not objected to even by children. Dall (Gaz zetta degli Osp., Jan. 14, '93).
Sixty-one children were treated with lielianthus, in the form either of an alco holic tincture or of an alcoholic extract.
Of the former, from V, to 2 7, drachms were given daily in divided doses in a potion, and, of the latter, from '/, to 1 Ve. drachms. The remedy was well borne, even by the youngest infant. In the ma jority of cases the cure was as prompt as with quinine. Methylene-blue was admin istered to 36 children, varying in age from 23 days to 14 years. A cure was obtained in 10 cases, amelioration in 3, while in 14 the results were not conclusive. The drug was given in doses of from 3 V, to 6 grains in four equal parts, in the course of the day. The medicament was well borne and only in 1 case caused transient vesieal tenesmus. 14Ioncorvo (Le Bull. Med., Jan. 15, '93).
Upward of forty cases in children treated with methylene-blue, with en tirely satisfactory results. Dose em ployed varied from 4 to 7 1/,.. grains in the course of twenty-four hours, according to the age of the patient and the severity of the attack. The drug was of especial value in protracted and obstinate cases that resisted treatment by other means, and in cases of intermittent and remit tent not sufficiently severe to be of im mediate danger to life. In pernicious cases it would be judicious to join the subcutaneous injections of quinine bihy drochlorate. Its administration should be continued for several days after the subsidence of the fever and the disap pearance of the other symptoms. It may be given in solution in syrup of orange peel and syrup of canella. To larger children it may be administered in tab let, cachet, or capsule. Ferreira Mull. Gen. de Then, .June 15, '93).
Living malarial parasites subjected, under the microscope, to the action of a solution of quinine 1 to 5000, and of a solution of methylene-blue 1 to 20,000. The former did not at all affect the move ment of the plasmodia, not even after ten hours; thc latter destroyed it very soon, and in about half an hour the microbes were stained a beautiful blue. H. Rosin (Schmidt's Jahrbiicher, May 15, '94).
Phenocoll should be 'substituted in pregnant women suffering from malaria, this drug having, no action on the uterus; in doses of 22 grains divided in 4 cachets, to bc taken 5, 4, 3, and 2 hours before a febrile paroxysm is due. Titone (Rif. Med., NOV. 24, '94).