Euchinin is superior to quinine in be ing tasteless and requiring a smaller dose to reduce ternperature. It does cause cinclionism. In from 10- to 15-grain (loses it is equal to quinine sulphate in 20- to 30-grain doses. St. George Gray (Post-grad., May, '93).
Myrrh recommended, in the treatment of malaria, in the following formula: Quinine, 40 grains; pulverized myrrh, 20 grains; powdered licorice, 10 grains. Forty pills are made, one of which is to be taken every two hours. The myrrh increases the number of white blood corpuscles, which are scavengers of the blood, and therefore more easily elimi Dale the malarial plasmodium. Aaron Jeffrey (Med. Rec., Aug. 20, '9S).
There are cases of chronic intermit tent fever, with large tumefaction of the spleen, that, after having resisted the action of quinine, arsenic, methylene blue, eucalyptus, and piperine, are bene fited by ergot. Jacobi (Med. News, Oct. 22, TS).
In those cases of malaria in which there is an idiosyncrasy to quinine, sali ein and sodium saliey-late are of great advantage. J. R. Gilbert (Jour. Amer. Med. Assoc., Nov. 12, '9S).
Creasote treatment for malarial fevers in children which combines every-thing that is necessary, even in very severe eases; it is easily applied, acts rapidly and continuously, and with certainty. Pure beech-wood ereasote, 15 to 20 min ims for a child of 1 year, or 30 to 60 minims for an adult, is mixed with am equal quantity, or more, of olive-oil, and rubbed, for from five to ten minutes, over the chest, abdomen, axillm, and sides. The oil is only employed to coun teract the tingling and burning occasion ally produced by the creasote. A. O. Fitzgerald (Brit. Med. Jour., July 15, '99).
Guaiacol surpasses any remedy so far recommended for malaria. In personal experience it has cured every case, in some of which quinine had been tried and failed. C. J. Whalen (Merek's Archives, Apr., 1900).
Methy-lene-blue will destroy malarial parasites in many cases, but is less cer tain than quinine, and it is probably' most valuable in chronic cases, but has no advantage over quinine. The effects of methylene-blue are ordinarily more unpleasant than quinine. It is useful in
cases that cannot take quinine on ac count of some idiosyncrasy- to it. Its use in cases of pregnancy is undeter mined. It is probably valuable in treat ing hminaturic and hmmoglobinuric fevers on account of its diuretic action; this has yet to be determined. The writers have had no chalice to test its use in such cases. They believe that quinine acts more quickly and is much more certain and more reliable than methylene-blue. Moore and Allison (Medical News, Dec. 6, 1902).
Prophylaxis. — General measures of prophylaxis may be adopted in accord ance with the facts k-nown of the etiology of the infection and which have been referred to in the section on that subject. Although recent researches all tend to prove that infection occurs by other channels than the alimentary tract, notably the skin, it is the part of pru dence to sterilize by boiling water com ing from infected regions. The proph ylactic value of quinine is not to be over looked, and infection may often be pre vented by taking the drug in doses of 6 grains, or even less, in the twenty-four hours.
To reduce, as much as possible, the quantity of the malarial ferment that enters into the system through the air breathed is sought to be achieved by avoiding agricultural operations during those hours at which the malarious in fluence is most potent, viz.: about sun rise and sunset. Another point of the greatest importance is to avoid breathing the air in close contact with the soil, as the malarious poison rises only a short distance in a vertical direction. It is ad visable to keep the windows closed in the morning and during the early hours of the evening, especially if any excavation should be going on in the neighborhood. Flowers should be entirely- excluded from houses when malaria is rife, or the utmost vigilance should be taken to se cure thorough ventilation. Tommasi t 4, f 11, me and 1Zoman t'.. '' .
it. f quinine as a prophyble , :I it I Until striit surveillance in n al.iiions region. Of :30 SO]. .'1"A ;:i CI\ &II the drug regularly: the ft: • r • te d red from fever, those •rt n entirtly free. 1.. Cen it Med. \ .\ ng., '95).