In children hydrobromate of quinine of service in same doses as other salts of the alkaloid. Especially useful in nervous, excitable children. Solubility further promoted by- association with antipyrine. Comby (La Med. Mod., Aug. 28, '95).
Roux's serum employed in 2 eases of to.,1. In the first there were •ult tists of 1,•mperature and t .11.11, (ere The SeC.011,1 eftSe, r‘,11 .111,r rt 11,0, lid SlIONVed 110 Treille (Sem. MCA. 1).
312, .
t,naia,,1 us,,I in the treatment of ma I.r, intermittent fevers: 15 minims rubbed into the axilla and covered a It ,,41,11. The average fall of tem p wine ' hour was 1.6°, in 13/, I.. Ins, and after 4 hours the aver . ge fall N,lis 3°. The fall of temperature ‘,04 ae(t1111.11111ed by a free perspiration 4.1 d a learked improvement in the condi •I. 11 1111,1 c, infort of the patient. No de } r,ssi,.n was noticed. Rogers (Then May 15, '96; from Indian Med. Gaz., Jan., '90).
l'iite,reminiin doses of creasote, rubbed into the axilla and then covered with totton-e ool, used in eight cases of se vcre intermittent fever with tempera tuns varying from 103.2° to 104.4° F., the temperature being either stationary r rising at the time the drug was ap plied. In every case perspiration, usually free, was produced in from half an hour to two hours, and was accompanied by a marked fall of temperature, averaging 1 6° F. within 3/, hour, 2.3° after Pi. heurs. and 3° within 4 hours after the use of the drug. At the same time all tbe distressing symptoms, including the -everc headache always present with high fever in these cases, were decidedly re :ieved. Leonard Rogers (Brit. Med. Icur., Jan. 4, '99).
Seven eases of malaria treated with 1, ethylene-blue in doses of 1 '/, grains, in car sules, given six or eight times in the day. The rapid cessation of the at tack N, as striking. :Microscopical exami natien showed that the plasmodia disap peared from the blood later than the febrile attacks. Duration of the treat ment extended over S days as a mini mum and 23 days as maximum. It was determined by the disappearance of the flasmodia and of the splenic enlarge:. merit. Rottger (Deut. med. Woch., Apr. .9, :96).
Analgen in doses of 4 to 15 grains in t.N%enty-four hours used in 33 eases of
malaria in children is a useful adjuvant to quinine, and a substitute when the latter cannot be administered. Moncorvo (Bull. de l'Aead. de Mal., Nov. 10, '96).
Methylene-blue should only be used in simple intermittent fevers, and it would be dangerous to substitute it for quinine in the treatment of continued fevers and in grave cases. It is only indicated, IN hen, for some cause, the use of quinine is contra-indicated, especially when, even in small doses, it produces hremoglobi nuria. The daily dose in the adult is from 9 to 15 gTains; sometimes it pro duces a slight cystitis that ceases when the drug is discontinued. Cardamatis (Gaz. des 114., Apr. 15, '97).
Phenocoll, though no substitute for quinine as an antiperiodic in itnpaludism, has valuable analgesic properties, and in small doses distributed over the twenty four hours, or preferably administered from three to five hours before the access, alleviates the pains of the ague-fit and in certain cases refractory to quinine has even shortened its duration. However, Quirogne has found that, even in moder ate doses, phenocoll has the disadvantage of causing symptoms of collapse. Edi torial (Sem. Mal., No. 54, Nov. 17, '97).
In the treatment of mild forms of ma larial fever, while the preparations of bark may not act so rapidly as quinine, they are often more efficacious. After the paroxysms have once been arrested they are not so apt to recur. If the bark is given continuously for several weeks the patient's general condition is much better than it is in those cases in which quinine in small or moderate doses has, been persistently- taken. B. Robinson (Med. Rec., Jan. 15, '98).
Perfect cure in cases of undoubted ma laria, which had proved intractable to quinine in large doses by small doses of nuclein (1 drop every two or three hours), which caused a prompt disap pearance of the cachexia, migraine, gas tro-intestinal disturbances, hmmaturia, general depression, and other so-called malarial symptoms under which the pa tients were suffering. Editorial (Cincin nati Lancet-Clinic, Apr. 30, '98).